---
abstract: 'Xeroderma pigmentosum (XP) is a rare genetic disorder associated with multiple oculocutaneous and neurological manifestations. It occurs due to deficiency of the enzymes responsible for repairing ultraviolet radiation-induced DNA damage. Persistence of un-repaired DNA results in somatic mutations, leading to neoplasia of the skin and ocular surface. As this condition is rare, only isolated case reports of XP with ocular surface squamous neoplasia (OSSN) are found in literature. '
altloc:
  - http://www.ojhas.org/issue47/2013-3-15.html
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  - ~
  - ~
  - ~
  - ajayrkamath@yahoo.com
  - ~
creators_name:
  - family: Nayak
    given: RR
    honourific: ''
    lineage: ''
  - family: Kamath
    given: GM
    honourific: ''
    lineage: ''
  - family: Kamath
    given: MM
    honourific: ''
    lineage: ''
  - family: Kamath
    given: AR
    honourific: ''
    lineage: ''
  - family: D'Souza
    given: S
    honourific: ''
    lineage: ''
date: 2013-11-15
date_type: published
datestamp: 2015-02-21 14:35:06
department: ~
dir: disk0/00/00/97/02
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editors_id:
  - Kakkilaya BS
editors_name:
  - family: Kakkilaya
    given: Srinivas
    honourific: Dr
    lineage: ''
eprint_status: archive
eprintid: 9702
fileinfo: /9702/1.hassmallThumbnailVersion/2013-3-15.pdf;/9702/1/2013-3-15.pdf
full_text_status: public
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keywords: Ocular surface squamous neoplasia; Xeroderma pigmentosum
lastmod: 2015-04-20 11:44:40
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 3(15)
pagerange: ~
pubdom: TRUE
publication: Online Journal of Health and Allied Sciences
publisher: Kakkilaya BS
refereed: TRUE
referencetext: "1.\tTrosko JE, Krause D, Isoun M. Sunlight-induced pyrimidine dimmers in human cells in vitro. Nature. 1970;228:358–359.\r\n2.\tKraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum — cutaneous, ocular and neurologic abnormalities in 830 published cases. Arch Dermatol. 1987;123:241–250.\r\n3.\tLee GA, Hirst LW. Ocular surface squamous neoplasia. Surv Ophthalmol. 1995;39:429–450.\r\n4.\tGoyal JL, Rao VA, Srinivasan R, Agrawal K. Oculocutaneous manifestations in xeroderma pigmentosa. Br J Ophthalmol. 1994;78:295–297.\r\n5.\tBasti S, Macsai MS. Ocular surface squamous neoplasia: a review. Cornea. 2003;22:687–704.\r\n6.\tEric JC, Campbell RJ, Leisgang J. Conjunctival and corneal intraepithelial and invasive neoplasia. Ophthalmology. 1986;93:176–183.\r\n7.\tDivine RD, Anderson RL. Nitrous oxide cryotherapy for intraepithelial epithelioma of the conjunctiva. Arch Ophthalmol. 1983;101:782–786.\r\n8.\tFraunfelder FT, Wingfield D. Management of intraepithelial epitheliomas and squamous cell carcinomas. Am J Ophthalmol. 1983;95:359–363."
relation_type: []
relation_uri: []
reportno: ~
rev_number: 10
series: ~
source: ~
status_changed: 2015-02-21 14:35:06
subjects:
  - OJHAS
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum
type: journale
userid: 4338
volume: 12
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