?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Red+Cell+Genetic+Markers+in+Malarial+Susceptibility+and+Selective+Advantage+Hypothesis&rft.creator=Balgir%2C+RS&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Malaria+is+still+a+serious+public+health+challenge+in+many+parts+of+the+world+including+India.+Human+genetic+susceptibility+to+malaria+varies+from+individual+to+individual+depending+upon+the+genetic+constitution+and+from+region+to+region+based+on+geo-ecological+and+climatic+conditions.+In+the+present+study%2C+intravenous+334+random+blood+samples+of+unrelated+adult+individuals+belonging+to+Mongoloid+ethnic+stock+were+taken+after+informed+consent+from+the+endemic+localities+of+Arunachal+Pradesh%2C+Assam+and+Nagaland+to+find+out+the+relationship+between+the+abnormal+hemoglobin+and+G6PD+enzyme+deficiency%2C+and+susceptibility+to+malaria.+Abnormal+hemoglobin+E+and+G6PD+enzyme+deficiency+seem+to+interact+with+malarial+parasite+in+such+a+way+that+they+probably+provide+decreased+susceptibility+or+inhibitory+effect+or+increased+resistance.+Genetic+alterations+in+human+genome+are+maintained+in+the+specific+population+by+natural+selection+to+protect+the+host+against+the+malarial+infection.++These+findings+are+consistent+with+those+studies+which+support+the+notion+of+selective+genetic+advantage+hypothesis+against+the+malaria+infection.&rft.publisher=Kakkilaya+BS&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2014-02-20&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F9712%2F1%2F2013-4-5.pdf&rft.identifier=++Balgir%2C+RS++(2014)+Red+Cell+Genetic+Markers+in+Malarial+Susceptibility+and+Selective+Advantage+Hypothesis.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F9712%2F