?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Co-Variations+among+Cognition%2C+Cerebellar%0D%0ADisorders+and+Cortical+Areas+With%0D%0ARegional+Glucose-Metabolic+Activities+in+a%0D%0AHomogeneous+Sample+with+Uner+Tan+Syndrome%3A%0D%0AHolistic+Functioning+of+the+Human+Brain&rft.creator=Tan%2C+Prof.+Dr.++Uner&rft.subject=Applied+Cognitive+Psychology&rft.subject=Behavioral+Analysis&rft.subject=Behavioral+Neuroscience&rft.subject=Brain+Imaging&rft.subject=Clinical+Psychology&rft.subject=Cognitive+Psychology&rft.subject=Evolutionary+Psychology&rft.subject=Neuroanatomy&rft.subject=Neurolinguistics&rft.subject=Neurology&rft.subject=Neurophysiology&rft.subject=Neuropsychology&rft.subject=Neuropsychiatry&rft.subject=Philosophy+of+Science&rft.subject=Physiological+Psychology&rft.subject=Psychophysiology&rft.subject=Social+Psychology&rft.description=Patients+with+Uner+Tan+syndrome+(UTS)+exhibit+habitual+quadrupedal+locomotion+(QL)%2C+intellectual+disability%2C+dysarthric+speech+and+truncal+ataxia.+Examination+of+cognitive+ability+in+this+syndrome+has+not+yet+been+demonstrated+in+the+scientific+literature.++Aims%3A+(i)+To+analyze+the+cognitive+abilities+of+the+siblings+with+UTS%3B+(ii)+to+assess+the+grade+of+their+ataxia+in+relation+to+cerebellar+disorders%3B+(iii)+to+measure+the+metabolic+activities+of+various+cerebral+regions+in+comparison+with+healthy+individuals%3B+(iv)+to+detect+the+interrelationships+among+all+of+the+measured+variables+(IQ+test+scores%2C+ataxia+scores%2C+cerebro-cerebellar+areas+and+their+metabolic+activity+levels)+to+reveal+the+holistic+activity+of+the%0D%0Abrain.++The+Minimental+State+Examination+(MMSE)+and+Wechsler+Adult+Intelligence+Scale+(WAIS-R)+were+applied+to+the+affected+cases+and+healthy+subjects.+Cerebellar+disorders+were+assessed+by+the+International+Cooperative+Ataxia+Rating+Scale+(ICARS).+Brain+MRI+scans+were+performed+and+cerebro-cerebellar+areas+were+measured+on+MRI+scans%2C+including+their+metabolic+activities+(SUV)%2C+measured+by+positron+emission+tomography+(PET)+scanning.+MMSE+and+WAIS-R+scores+both+correlated+with+cerebro-cerebellar+areas.+Cerebello-vermial+areas+and+their+metabolic+activities+were+significantly+smaller+in+patients+than+in+normal+controls%3B+areas+of+the+remaining+structures+were+not+significantly+different+between+patients+and+healthy+subjects.+Brain+areas+significantly+inter-correlated%3A+ICARS+negatively+correlated+with+WAIS-R%2CMMSE+scores%2C+SUV%2C+and+cerebro-cerebellar+areas%2C+which+significantly+correlated+with+each+other.+The+results+suggested+(i)+ICARS+may+not+only+be+a+test+for+cerebellar+disorders%2C+but+also+may+be+related+to+global+functioning+of+all+of+the%0D%0Acerebro-cerebellar+regions%3B+(ii)+ICARS%2C+WAIS-R+and+MMSE+may+be+measures+of+emergent+properties+of+the+holistic%0D%0Aactivity+of+the+brain%3B+(iii)+the+psychomotor+disorders+in+UTS+may+be+related+to+decreased+brain+metabolism.&rft.contributor=Tarlaci%2C+Prof.+Dr.++Sultan&rft.date=2014-07-09&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F9756%2F1%2FTAN%2520PAPER%2520NQ%25202014%2520%25281%2529.pdf&rft.identifier=++Tan%2C+Prof.+Dr.+Uner++(2014)+Co-Variations+among+Cognition%2C+Cerebellar+Disorders+and+Cortical+Areas+With+Regional+Glucose-Metabolic+Activities+in+a+Homogeneous+Sample+with+Uner+Tan+Syndrome%3A+Holistic+Functioning+of+the+Human+Brain.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F9756%2F