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"Statistical mechanics of neocortical interactions: A scaling paradigm applied to electroencephalography"^^ .
"A series of papers has developed a statistical mechanics of neocortical interactions (SMNI), deriving aggregate behavior of experimentally observed columns of neurons from statistical electrical-chemical properties of synaptic interactions. While not useful to yield insights at the single neuron level, SMNI has demonstrated its capability in describing large-scale properties of short-term memory and electroencephalographic (EEG) systematics. The necessity of including nonlinear and stochastic structures in this development has been stressed. In this paper, a more stringent test is placed on SMNI: The algebraic and numerical algorithms previously developed in this and similar systems are brought to bear to fit large sets of EEG and evoked potential data being collected to investigate genetic predispositions to alcoholism and to extract brain \"signatures\" of short-term memory. Using the numerical algorithm of Very Fast Simulated Re-Annealing, it is demonstrated that SMNI can indeed fit this data within experimentally observed ranges of its underlying neuronal-synaptic parameters, and use the quantitative modeling results to examine physical neocortical mechanisms to discriminate between high-risk and low-risk populations genetically predisposed to alcoholism. Since this first study is a control to span relatively long time epochs, similar to earlier attempts to establish such correlations, this discrimination is inconclusive because of other neuronal activity which can mask such effects. However, the SMNI model is shown to be consistent with EEG data during selective attention tasks and with neocortical mechanisms describing short-term memory previously published using this approach. This paper explicitly identifies similar nonlinear stochastic mechanisms of interaction at the microscopic-neuronal, mesoscopic-columnar and macroscopic-regional scales of neocortical interactions. These results give strong quantitative support for an accurate intuitive picture, portraying neocortical interactions as having common algebraic or physics mechanisms that scale across quite disparate spatial scales and functional or behavioral phenomena, i.e., describing interactions among neurons, columns of neurons, and regional masses of neurons."^^ .
"1991" .
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"6" .
"44" .
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"Physical Review A"^^ .
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"Lester"^^ .
"Ingber"^^ .
"Lester Ingber"^^ .
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"Statistical mechanics of neocortical interactions: A scaling paradigm applied to electroencephalography (Postscript)"^^ .
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"smni91_eeg.ps"^^ .
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"HTML Summary of #98 \n\nStatistical mechanics of neocortical interactions: A scaling paradigm applied to electroencephalography\n\n" .
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"Computational Neuroscience" .
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"Statistical Models" .
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