Experimental Protocols

The paper builds on earlier an earlier blog by Ally Palmer called 'Can animals volunteer to participate in research?' We use the questions rasied by Ally to examine together the different ways that scientific researchers talk about animals' volunteering in research papers and reflect on the ethical importance of this discourse.

This book chapter is forthcoming in the book Multi-Species Dementia Studies: Towards an Interdisciplinary Approach, edited by Nick Jenkins, Anna Jack-Waugh, and Louise Ritchie, from Bristol University Press. The chapter brings work by Davies and Gorman’s on how patient representatives review research proposals that use animal models in dementia research with Richard Milne’s work on the emergence, development, and ‘calibration’ of animal models over the last 40 years of Alzheimer’s research. Bringing these projects together enables us to explore how multispecies relations are made in Alzheimer's research, and how people affected by dementia are placed in several ways through these processes, only some of which they are aware of and thus able to affect.

Genetically modified or ‘transgenic’ mice are a routine experimental tool in biomedical research, commonly produced by injecting DNA into one-cell embryos. These animals were independently invented in 1980 by multiple university groups in the United States and Europe that combined expertise in mouse developmental biology and recombinant DNA techniques, or ‘genetic engineering’. In this article, I examine this multiple invention and argue that research strategies, experimental practices, and funding arrangements that led to transgenic mice are best described as tinkering. These creative and speculative endeavors, combined with partial knowledge of what was happening in competing laboratories, created a fruitful atmosphere for research which led to the multiple invention. The tinkering was, however, underpinned by infrastructures that were crucial to success, some long established, such as mouse supply or embryological tools, and some emerging, such as the informal exchange of isolated genes.

The third issue of the AnNex Newsletter, December 2019

In this paper, in Tecnoscienza, we investigate translation in biomedicine by exploring how researchers supported by the British Pharmacological Society’s Integrative Pharmacology Fund (IPF) have responded to increasing translational aspirations within pre-clinical animal research.