Theories of developmental dyslexia: Insights from a multiple case study of dyslexic adults

Ramus, Franck and Rosen, Stuart and Dakin, Steven C. and Day, Brian L. and Castellote, Juan M. and White, Sarah and Frith, Uta (2002) Theories of developmental dyslexia: Insights from a multiple case study of dyslexic adults. [Preprint] (Unpublished)

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A multiple case study was conducted in order to assess three leading theories of developmental dyslexia: the phonological, the magnocellular (auditory and visual) and the cerebellar theories. Sixteen dyslexic and 16 control university students were administered a full battery of psychometric, phonological, auditory, visual and cerebellar tests. Individual data reveal that all 16 dyslexics suffer from a phonological deficit, 10 from an auditory deficit, 4 from a motor deficit, and 2 from a visual magnocellular deficit. Results suggest that a phonological deficit can appear in the absence of any other sensory or motor disorder, and is sufficient to cause a literacy impairment, as demonstrated by 5 of the dyslexics. Auditory disorders, when present, aggravate the phonological deficit, hence the literacy impairment. However, auditory deficits cannot be characterised simply as rapid auditory processing problems, as would be predicted by the magnocellular theory. Nor are they restricted to speech. Contrary to the cerebellar theory, we find little support for the notion that motor impairments, when found, have a cerebellar origin, or reflect an automaticity deficit. Overall, the present data support the phonological theory of dyslexia, while acknowledging the presence of additional sensory and motor disorders in certain individuals.

Item Type:Preprint
Additional Information:Supplementary material:
Keywords:dyslexia; phonology; audition; vision; magnocellular function; motor control; cerebellum
Subjects:Neuroscience > Neuropsychology
Psychology > Developmental Psychology
Psychology > Psychophysics
Psychology > Perceptual Cognitive Psychology
Psychology > Clinical Psychology
Neuroscience > Behavioral Neuroscience
ID Code:2350
Deposited By: Ramus, Dr Franck
Deposited On:26 Jul 2002
Last Modified:11 Mar 2011 08:54

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

Adlard A, Hazan V. Speech perception in children with specific reading difficulties (dyslexia). Quarterly Journal of Experimental Psychology 1998; 51A: 153-177.

Ahissar M, Protopapas A, Reid M, Merzenich MM. Auditory processing parallels reading abilities in adults. Proc Natl Acad Sci U S A 2000; 97: 6832-6837.

Baker RJ, Rosen S. Evaluation of maximum-likelihood threshold estimation with tone-in-noise masking. British Journal of Audiology 2001; 35: 43-52.

Bishop DV, Bishop SJ, Bright P, James C, Delaney T, Tallal P. Different origin of auditory and phonological processing problems in children with language impairment: evidence from a twin study. J Speech Lang Hear Res 1999; 42: 155-68.

Bradley L, Bryant PE. Difficulties in auditory organisation as a possible cause of reading backwardness. Nature 1978; 271: 746-747.

Brady S, Shankweiler D. Phonological processes in literacy. Hillsdale, NJ: Lawrence Erlbaum, 1991.

Brady S, Shankweiler D, Mann V. Speech perception and memory coding in relation to reading ability. J Exp Child Psychol 1983; 35: 345-67.

Brainard DH. The Psychophysics Toolbox. Spatial Vision 1997; 10: 433-436.

Brown TE. Brown Attention-Deficit Disorder Scales. San Antonio: The Psychological Corporation, 1996.

Brown WE, Eliez S, Menon V, Rumsey JM, White CD, Reiss AL. Preliminary evidence of widespread morphological variations of the brain in dyslexia. Neurology 2001; 56: 781-3.

Brunswick N, McCrory E, Price CJ, Frith CD, Frith U. Explicit and implicit processing of words and pseudowords by adult developmental dyslexics: A search for Wernicke's Wortschatz? Brain 1999; 122 ( Pt 10): 1901-17.

Carrell TD, Bradlow AR, Nicol TG, Koch DB, Kraus N. Interactive software for evaluating auditory discrimination. Ear Hear 1999; 20: 175-6.

Cornelissen P, Richardson A, Mason A, Fowler S, Stein J. Contrast sensitivity and coherent motion detection measured at photopic luminance levels in dyslexics and controls. Vision Res. 1995; 35: 1483-1494.

Cornelissen PL, Hansen PC, Gilchrist I, Cormack F, Essex J, Frankish C. Coherent motion detection and letter position encoding. Vision Research 1998; 38: 2181-91.

Demb JB, Boynton GM, Best M, Heeger DJ. Psychophysical evidence for a magnocellular pathway deficit in dyslexia. Vision Research 1998; 38: 1555-9.

Denckla MB, Rudel RG, Chapman C, Krieger J. Motor proficiency in dyslexic children with and without attentional disorders. Arch Neurol 1985; 42: 228-31.

Dow RS, Moruzzi G. The physiology and pathology of the cerebellum. Minneapolis: University of Minnesota Press, 1958.

Eden GF, Stein JF, Wood HM, Wood FB. Differences in eye movements and reading problems in dyslexic and normal children. Vision Research 1994; 34: 1345-1358.

Eden GF, VanMeter JW, Rumsey JM, Maisog JM, Woods RP, Zeffiro TA. Abnormal processing of visual motion in dyslexia revealed by functional brain imaging. Nature 1996; 382: 66-69.

Everatt J, Bradshaw MF, Hibbard PB. Visual processing and dyslexia. Perception 1999; 28: 243-254.

Farrag AF, Khedr EM, Abel-Naser W. Impaired parvocellular pathway in dyslexic children. Eur J Neurol 2002; 9: 359-63.

Fawcett AJ, Nicolson RI. The Dyslexia Screening Test. London: The Psychological Corporation, 1996.

Fawcett AJ, Nicolson RI. Dyslexia: The role of the cerebellum. In: Fawcett AJ, editor. Dyslexia: Theory and Good Practice. London: Whurr, 2001: 89-105.

Fawcett AJ, Nicolson RI, Dean P. Impaired performance of children with dyslexia on a range of cerebellar tasks. Annals of Dyslexia 1996; 46: 259-283.

Frederickson N, Frith U, Reason R. Phonological Assessment Battery. Windsor: NFER-NELSON, 1997.

Friston KJ, Büchel C. Attentional modulation of effective connectivity from V2 to V5/MT in humans. Proc Natl Acad Sci U S A 2000; 97: 7591-6.

Galaburda AM, Sherman GF, Rosen GD, Aboitiz F, Geschwind N. Developmental dyslexia: four consecutive patients with cortical anomalies. Ann Neurol 1985; 18: 222-33.

Gathercole SE, Baddeley AD. The Children's Test of Nonword Repetition. London: The Psychological Corporation, 1996.

Geschwind N, Galaburda AM. Cerebral lateralization. Biological mechanisms, associations, and pathology: I. A hypothesis and a program for research. Arch Neurol 1985; 42: 428-59.

Grant AC, Zangaladze A, Thiagarajah M, Saathian K. Tactile perception in dyslexics. Neuropsychologia 1999; 37: 1201-1211.

Grigorenko EL. Developmental dyslexia: an update on genes, brains, and environments. J Child Psychol Psychiatry 2001; 42: 91-125.

Hazan V, Barrett S. The development of phonemic categorisation in children aged 6 to 12. Journal of Phonetics 2000; 28: 377-396.

Heath SM, Hogben JH, Clark CD. Auditory temporal processing in disabled readers with and without oral language delay. J Child Psychol Psychiatry 1999; 40: 637-47.

Hill NI, Bailey PJ, Griffiths YM, Snowling MJ. Frequency acuity and binaural masking release in dyslexic listeners. J Acoust Soc Am 1999; 106: L53-8.

Ivry R, B, Keele SW. Timing functions of the cerebellum. Journal of Cognitive Neuroscience 1989; 1: 136-152.

Johannes S, Kussmaul CL, Munte TF, Mangun GR. Developmental dyslexia: passive visual stimulation provides no evidence for a magnocellular processing defect. Neuropsychologia 1996; 34: 1123-7.

Klatt DH. Software for a cascade/parallel formant synthesizer. Journal of the Acoustical Society of America 1980; 67: 971-995.

Kronbichler M, Hutzler F, Wimmer H. Dyslexia: Verbal impairments in the absence of magnocellular impairments. Neuroreport 2002; 13: 617-620.

Lamme VA, Roelfsema PR. The distinct modes of vision offered by feedforward and recurrent processing. Trends Neurosci 2000; 23: 571-9.

Legge GE. Sustained and transient mechanisms in human vision: temporal and spatial properties. Vision Research 1978; 18: 69-81.

Leonard CM, Eckert MA, Lombardino LJ, Oakland T, Kranzler J, Mohr CM, et al. Anatomical risk factors for phonological dyslexia. Cereb Cortex 2001; 11: 148-57.

Levitt H. Transformed up-down methods in psychoacoustics. Journal of the Acoustical Society of America 1971; 49: 467-476.

Liberman AM, Mattingly IG. The motor theory of speech perception revised. Cognition 1985; 21: 1-36.

Livingstone M, Rosen G, Drislane F, Galaburda A. Physiological and anatomical evidence for a magnocellular defect in developmental dyslexia. Proceedings of the National Academy of Science 1991; 88: 7943-7947.

Lorenzi C, Dumont A, Füllgrabe C. Use of temporal envelope cues by children with developmental dyslexia. Journal of Speech, Language and Hearing Research 2000; 43: 1367-1379.

Lovegrove WJ, Bwoling A, Badcock B, Blackwood M. Specific reading disability: differences in contrast sensitivity as a function of spatial frequency. Science 1980; 210: 439-440.

Manis FR, Mcbride-Chang C, Seidenberg MS, Keating P, Doi LM, Munson B, et al. Are speech perception deficits associated with developmental dyslexia? J.Exp.Child Psychol. 1997; 66: 211-235.

Marshall CM, Snowling MJ, Bailey PJ. Rapid auditory processing and phonological ability in normal readers and readers with dyslexia. Journal of Speech, Language and Hearing Research 2001; 44: 925-940.

Martin F, Lovegrove W. Flicker contrast sensitivity in normal an specifically disabled readers. Perception 1987; 16: 215–221.

McAnally KI, Stein JF. Auditory temporal coding in dyslexia. Proceedings of the National Academy of Sciences 1996; 263: 961-965.

McArthur GM, Hogben JH. Auditory backward recognition masking in children with a specific language impairment and children with a specific reading disability. J Acoust Soc Am 2001; 109: 1092-100.

McCrory E. A neurocognitive investigation of phonological processing in dyslexia. London: University College London, 2001.

McCrory E, Frith U, Brunswick N, Price C. Abnormal functional activation during a simple word repetition task: A PET study of adult dyslexics. J Cogn Neurosci 2000; 12: 753-62.

Mody M, Studdert-Kennedy M, Brady S. Speech perception deficits in poor readers: auditory processing or phonological coding? J Exp Child Psychol 1997; 64: 199-231.

Neale MD. Neale Analysis of Reading Ability Revised. Windsor: NFER-NELSON, 1997.

Nelson HE. National Adult Reading Test - second edition. Windsor: NFER-NELSON, 1991.

Nicolson RI, Fawcett AJ. Automaticity: a new framework for dyslexia research? Cognition 1990; 35: 159-182.

Nicolson RI, Fawcett AJ, Berry EL, Jenkins IH, Dean P, Brooks DJ. Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults. Lancet 1999; 353: 1662-1667.

Nicolson RI, Fawcett AJ, Dean P. Time estimation deficits in developmental dyslexia: evidence of cerebellar involvement. Proc.R.Soc.Lond B Biol.Sci. 1995; 259: 43-47.

Nicolson RI, Fawcett AJ, Dean P. Dyslexia, development and the cerebellum. Trends Neurosci 2001; 24: 515-6.

Nittrouer S. Do temporal processing deficits cause phonological processing problems? J Speech Lang Hear Res 1999; 42: 925-942.

Paulesu E, Démonet J-F, Fazio F, McCrory E, Chanoine V, Brunswick N, et al. Dyslexia: Cultural Diversity and Biological Unity. Science 2001: 2165-2167.

Paulesu E, Frith U, Snowling M, Gallagher A, Morton J, Frackowiak RSJ, et al. Is developmental dyslexia a disconnection syndrome? Evidence from PET scanning. Brain 1996; 119: 143-157.

Pelli DG. The VideoToolbox software for visual psychophysics: transforming number into movies. Spatial Vision 1997; 10: 437-442.

Pugh KR, Mencl WE, Shaywitz BA, Shaywitz SE, Fulbright RK, Constable RT, et al. The angular gyrus in developmental dyslexia: task-specific differences in functional connectivity within posterior cortex. Psychol Sci 2000; 11: 51-6.

Rae C, Lee MA, Dixon RM, Blamire AM, Thompson CH, Styles P, et al. Metabolic abnormalities in developmental dyslexia detected by 1H magnetic resonance spectroscopy. Lancet 1998; 351: 1849-52.

Ramus F. Dyslexia - Talk of two theories. Nature 2001; 412: 393-395.

Ramus F, Pidgeon E, Frith U. The relationship between motor control and phonology in dyslexic children. Journal of Child Psychology and Psychiatry in press.

Raymond J, Sorenson R. Visual motion perception in children with dyslexia: normal detection but abnormal integration. Visual Cognition 1998; 5: 389-404.

Reed MA. Speech perception and the discrimination of brief auditory cues in reading disabled children. Journal of Experimental Child Psychology 1989; 48: 270-292.

Rosen S, Manganari E. Is there a relationship between speech and nonspeech auditory processing in children with dyslexia? J Speech Lang Hear Res 2001; 44: 720-36.

Schulte-Körne G, Deimel W, Bartling J, Remschmidt H. Auditory processing and dyslexia: evidence for a specific speech processing deficit. NeuroReport 1998a; 9: 337-340.

Schulte-Körne G, Deimel W, Bartling J, Remschmidt H. Role of auditory temporal processing for reading and spelling disability. Percept Mot Skills 1998b; 86: 1043-1047.

Shaywitz BA, Shaywitz SE, Pugh KR, Mencl WE, Fulbright RK, Skudlarski P, et al. Disruption of posterior brain systems for reading in children with developmental dyslexia. Biol Psychiatry 2002; 52: 101-10.

Shaywitz SE, Shaywitz BA, Pugh KR, Fulbright RK, Constable RT, Mencl WE, et al. Functional disruption in the organization of the brain for reading in dyslexia. Proc Natl Acad Sci U S A 1998; 95: 2636-41.

Skottun BC. The magnocellular deficit theory of dyslexia: the evidence from contrast sensitivity. Vision Res 2000; 40: 111-27.

Slaghuis WL, Ryan JF. Spatio-temporal contrast sensitivity, coherent motion, and visible persistence in developmental dyslexia. Vision Research 1999; 39: 651-668.

Snowling MJ. Phonemic deficits in developmental dyslexia. Psychological Research 1981; 43: 219-234.

Snowling MJ. Dyslexia. Oxford: Blackwell, 2000.

Snowling MJ, Stothard SE, McLean JM. Graded non-word reading test. Bury St. Edmunds: Thames Valley Test Company, 1996.

Stein J, Talcott J, Witton C. The sensorimotor basis of developmental dyslexia. In: Fawcett AJ, editor. Dyslexia: Theory and Good Practice. London: Whurr, 2001: 65-88.

Stein J, Walsh V. To see but not to read; the magnocellular theory of dyslexia. Trends Neurosci. 1997; 20: 147-152.

Stein JF, Fowler MS. Unstable binocular control in children with specific reading retardation. Journal of Research in Reading 1993; 16: 30-45.

Stoodley CJ, Talcott JB, Carter EL, Witton C, Stein JF. Selective deficits of vibrotactile sensitivity in dyslexic readers. Neuroscience Letters 2000; 295: 13-16.

Stringer R, Stanovich KE. On the possibility of cerebellar involvement in reading disability. 4th conference of the Society for Scientific Studies of Reading. San Diego, 1998.

Stuart GW, McAnally KI, Castles A. Can contrast sensitivity functions in dyslexia be explained by inattention rather than a magnocellular deficit? Vision Research 2001; 41: 3205-11.

Talcott JB, Witton C, McLean MF, Hansen PC, Rees A, Green GG, et al. Dynamic sensory sensitivity and children's word decoding skills. Proc Natl Acad Sci U S A 2000; 97: 2952-7.

Tallal P. Auditory temporal perception, phonics, and reading disabilities in children. Brain and Language 1980; 9: 182-98.

Tallal P, Miller S, Fitch RH. Neurobiological basis of speech: a case for the preeminence of temporal processing. Ann.N.Y.Acad.Sci. 1993; 682: 27-47.

van Daal V, van der Leij A. Developmental dyslexia: Related to specific or general deficits? Annals of Dyslexia 1999; 49: 71-104.

van der Lely HK. Specifically language impaired and normally developing children: Verbal passive vs. adjectival passive sentence interpretation. Lingua 1996a; 98: 243-272.

van der Lely HK, Stollwerk L. Binding theory and grammatical specific language impairment in children. Cognition 1997; 62: 245-290.

van der Lely HKJ. The Test of Active and Passive Sentences (TAPS). Available from author at the Centre for Developmental Language Disorders and Cognitive Neuroscience, University College London, London, UK, 1996b.

van der Lely HKJ. Advanced-Syntactic test of Pronominal reference (A-STOP). Available from author at the Centre for Developmental Language Disorders and Cognitive Neuroscience, University College London, London, UK, 1997.

van Ingelghem M, van Wieringen A, Wouters J, Vandenbussche E, Onghena P, Ghesquière P. Psychophysical evidence for a general temporal processing deficit in children with dyslexia. Neuroreport 2001; 12: 3603-3607.

Vellutino FR. Dyslexia: Research and Theory. Cambridge, MA: MIT Press, 1979.

Victor JD, Conte MM, Burton L, Nass RD. Visual evoked potentials in dyslexics and normals: failure to find a difference in transient or steady-state responses. Vis Neurosci 1993; 10: 939-46.

Watson AB, Pelli DG. QUEST: a Bayesian adaptive psychometric method. Percept Psychophys 1983; 33: 113-120.

Wechsler D. The Wechsler Adult Intelligence Scale 3rd edition UK. London: The Psychological Corporation, 1998.

Wilkins AJ. Visual stress. Oxford: Oxford University Press, 1995.

Wilkinson GS. Wide Range Achievement Test 3. Wilmington, DE: Wide Range, 1993.

Wimmer H, Mayringer H, Landerl K. Poor reading: A deficit in skill-automatization or a phonological deficit? Scientific Studies of Reading 1998; 2: 321-340.

Wimmer H, Mayringer H, Raberger T. Reading and dual-task balancing: Evidence against the automatization deficit explanation of developmental dyslexia. Journal of Learning Disabilities 1999; 32: 473-478.

Witton C, Talcott JB, Hansen PC, Richardson AJ, Griffiths TD, Rees A, et al. Sensitivity to dynamic auditory and visual stimuli predicts nonword reading ability in both dyslexic and normal readers. Curr Biol 1998; 8: 791-7.

Wolff PH. Impaired temporal resolution in developmental dyslexia. Ann.N.Y.Acad.Sci. 1993; 682: 87-103.

Wolff PH, Michel GF, Ovrut M, Drake C. Rate and timing precision of motor coordination in developmental dyslexia. Developmental Psychology 1990; 26: 349-359.

Wright BA, Lombardino LJ, King WM, Puranik CS, Leonard CM, Merzenich MM. Deficits in auditory temporal and spectral resolution in language- impaired children. Nature 1997; 387: 176-178.

Yap RL, van der Leij A. Testing the automatization deficit hypothesis of dyslexia via a dual- task paradigm. J Learn Disabil 1994; 27: 660-5.


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