Toward Cultural Oncology: The Evolutionary Information Dynamics of Cancer

Wallace, Rodrick and Wallace, Deborah and Wallace, Robert G. (2003) Toward Cultural Oncology: The Evolutionary Information Dynamics of Cancer. [Preprint]

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'Racial' disparities among cancers, particularly of the breast and prostate, are something of a mystery. For the US, in the face of slavery and its sequelae, centuries of interbreeding have greatly leavened genetic differences between 'Blacks' and 'whites', but marked contrasts in disease prevalence and progression persist. 'Adjustment' for socioeconomic status and lifestyle, while statistically accounting for much of the variance in breast cancer, only begs the question of ultimate causality. Here we propose a more basic biological explanation that extends the theory of immune cognition to include elaborate tumor control mechanisms constituting the principal selection pressure acting on pathologically mutating cell clones. The interplay between them occurs in the context of an embedding, highly structured, system of culturally specific psychosocial stress which we find is able to literally write an image of itself onto disease progression. The dynamics are analogous to punctuated equilibrium in simple evolutionary process

Item Type:Preprint
Keywords:cancer, cellular cognition, culture, evolution, information theory, interpenetration, mutator, punctuation
Subjects:Biology > Theoretical Biology
ID Code:2702
Deposited By: Wallace, Rodrick
Deposited On:09 Jan 2003
Last Modified:11 Mar 2011 08:55

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