Cogprints

Regulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity

Scheler, Dr. Gabriele (2003) Regulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity. [Preprint]

Full text available as:

[img]
Preview
 PDF
462Kb

Abstract

Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental factors, its functional consequences and modes of action are not well understood. In this paper we summarize relevant experimental evidence on NM receptor regulation (specifically dopamine D1 and D2 receptors) in order to explore its significance for neural and synaptic plasticity. We identify the relevant components of NM receptor regulation (receptor phosphorylation, receptor trafficking and sensitization of second-messenger pathways) gained from studies on cultured cells. Key principles in the regulation and control of short-term plasticity (sensitization) are identified, and a model is presented which employs direct and indirect feedback regulation of receptor efficacy. We also discuss long-term plasticity which involves shifts in receptor sensitivity and loss of responsivity to NM signals. Finally, we discuss the implications of NM receptor regulation for models of brain plasticity and memorization.We emphasize that a realistic model of brain plasticity will have to go beyond Hebbian models of long-term potentiation and depression to include plasticity in the distribution and efficacy of NM receptors.

Item Type:Preprint
Keywords:Hebbian plasticity, neuromodulators, dopamine, metaplasticity, LTP, learning, regulatory networks
Subjects:Neuroscience > Computational Neuroscience
Biology > Theoretical Biology
Neuroscience > Neuropharmacology
ID Code:2836
Deposited By: Scheler, Dr Gabriele
Deposited On:17 Mar 2003
Last Modified:11 Mar 2011 08:55

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

[AbrahamBear96]

W C Abraham and M F Bear.

Metaplasticity: the plasticity of synaptic plasticity.

Trends Neurosci, 19:126-30, 1996.

[AizmanOetal2000]

O Aizman, H Brismar, P Uhlen, E Zettergren, A I Levey, H Forssberg,

P Greengard, and A Aperia.

Anatomical and physiological evidence for D1 and D2 dopamine

receptor colocalization in neostriatal neurons.

Nat Neurosci, 3:226-30, 2000.

[BatesMDetal91]

M D Bates, M G Caron, and J R Raymond.

Desensitization of DA1 dopamine receptors coupled to adenylyl

cyclase in opossum kidney cells.

Am J Physiol, 260:F937-45, 1991.

[BatesMDetal93]

M D Bates, C L Olsen, B N Becker, F J Albers, J P Middleton, J G Mulheron, S L

Jin, M Conti, and J R Raymond.

Elevation of cAMP is required for down-regulation, but not

agonist-induced desensitization, of endogenous dopamine D1 receptors in

opossum kidney cells. Studies in cells that stably express a rat cAMP

phosphodiesterase (rPDE3) cDNA.

J Biol Chem, 268:14757-63, 1993.

[BehrJetal2000]

J Behr, T Gloveli, D Schmitz, and U Heinemann.

Dopamine depresses excitatory synaptic transmission onto rat

subicular neurons via presynaptic D1-like dopamine receptors.

J Neurophysiol, 84:112-9, 2000.

[BeurrierMalenka2002]

Corinne Beurrier and Robert C Malenka.

Enhanced inhibition of synaptic transmission by dopamine in the

nucleus accumbens during behavioral sensitization to cocaine.

J Neurosci, 22:5817-22, 2002.

[Bhalla2003]

Upinder S Bhalla.

Understanding complex signaling networks through models and

metaphors.[BindaAVetal2002]

Alicia V Binda, Nadine Kabbani, Ridwan Lin, and Robert Levenson.

D2 and D3 dopamine receptor cell surface localization mediated by

interaction with protein 4.1N.

Mol Pharmacol, 62:507-13, 2002.

[BlackLEetal94]

L E Black, E M Smyk-Randall, and D R Sibley.

Cyclic AMP-mediated desensitization of D1 dopamine receptor-coupled

adenylyl cyclase in NS20Y neuroblastoma cells.

Mol Cell Neurosci, 5:567-75, 1994.

[BlakelyBauman2000]

R D Blakely and A L Bauman.

Biogenic amine transporters: regulation in flux.

Curr Opin Neurobiol, 10:328-36, 2000.

[BlondOetal2002]

Olivier Blond, Francis Crepel, and Satoru Otani.

Long-term potentiation in rat prefrontal slices facilitated by

phased application of dopamine.

Eur J Pharmacol, 438:115-6, 2002.

[BouvierMetal88]

M Bouvier, W P Hausdorff, A De Blasi, B F O'Dowd, B K Kobilka, M G Caron, and

R J Lefkowitz.

Removal of phosphorylation sites from the beta 2-adrenergic receptor

delays onset of agonist-promoted desensitization.

Nature, 333:370-3, 1988.

[BursteinESetal97]

E S Burstein, T A Spalding, and M R Brann.

Pharmacology of muscarinic receptor subtypes constitutively

activated by G proteins.

Mol Pharmacol, 51:312-9, 1997.

[CaiGetal2002]

Guoping Cai, Hoau-Yan Wang, and Eitan Friedman.

Increased dopamine receptor signaling and dopamine receptor-G

protein coupling in denervated striatum.

J Pharmacol Exp Ther, 302:1105-12, 2002.

[CantrellARetal99]

A R Cantrell, T Scheuer, and W A Catterall.

Voltage-dependent neuromodulation of Na+ channels by D1-like

dopamine receptors in rat hippocampal neurons.

J Neurosci, 19:5301-10, 1999.

[CarmanBenovic98]

C V Carman and J L Benovic.

G-protein-coupled receptors: turn-ons and turn-offs.

Curr Opin Neurobiol, 8:335-44, 1998.

[CepedaCetal93]

C Cepeda, N A Buchwald, and M S Levine.

Neuromodulatory actions of dopamine in the neostriatum are dependent

upon the excitatory amino acid receptor subtypes activated.

Proc Natl Acad Sci U S A, 90:9576-80, 1993.

[ChenJCetal99]

J C Chen, H J Su, L I Huang, and M M Hsieh.

Reductions in binding and functions of D2 dopamine receptors in the

rat ventral striatum during amphetamine sensitization.

Life Sci, 64:343-54, 1999.

[ChenXetal99]

X Chen, S B Kombian, J A Zidichouski, and Q J Pittman.

Dopamine depresses glutamatergic synaptic transmission in the rat

parabrachial nucleus in vitro.

Neuroscience, 90:457-68, 1999.

[ChuangTTetal96]

T T Chuang, L Paolucci, and A De Blasi.

Inhibition of G protein-coupled receptor kinase subtypes by

Ca2+/calmodulin.

J Biol Chem, 271:28691-6, 1996.

[ColginLLetal2003]

Laura Lee Colgin, Don Kubota, and Gary Lynch.

Cholinergic plasticity in the hippocampus.

Proc Natl Acad Sci U S A, 100:2872-7, 2003.

[CummingPetal2002]

Paul Cumming, Dean F Wong, Robert F Dannals, Nic Gillings, John Hilton, Ursula

Scheffel, and Albert Gjedde.

The competition between endogenous dopamine and radioligands for

specific binding to dopamine receptors.

Ann N Y Acad Sci, 965:440-50, 2002.

[DelgadoAetal2000]

A Delgado, A Sierra, E Querejeta, R F Valdiosera, and J Aceves.

Inhibitory control of the GABAergic transmission in the rat

neostriatum by D2 dopamine receptors.

Neuroscience, 95:1043-8, 2000.[DemchyshynLLetal2000]

L L Demchyshyn, F McConkey, and H B Niznik.

Dopamine D5 receptor agonist high affinity and constitutive activity

profile conferred by carboxyl-terminal tail sequence.

J Biol Chem, 275:23446-55, 2000.

[EgorovAVetal2002]

Alexei V Egorov, Bassam N Hamam, Erik Fransen, Michael E Hasselmo, and Angel A

Alonso.

Graded persistent activity in entorhinal cortex neurons.

Nature, 420:173-8, 2002.

[EnnisMetal2001]

M Ennis, F M Zhou, K J Ciombor, V Aroniadou-Anderjaska, A Hayar, E Borrelli,

L A Zimmer, F Margolis, and M T Shipley.

Dopamine D2 receptor-mediated presynaptic inhibition of olfactory

nerve terminals.

J Neurophysiol, 86:2986-97, 2001.

[FedericiMetal2002]

Mauro Federici, Silvia Natoli, Giorgio Bernardi, and Nicola B Mercuri.

Dopamine selectively reduces GABA(B) transmission onto dopaminergic

neurones by an unconventional presynaptic action.

J Physiol, 540:119-28, 2002.

[FergusonSS2001]

S S Ferguson.

Evolving concepts in G protein-coupled receptor endocytosis: the

role in receptor desensitization and signaling.

Pharmacol Rev, 53:1-24, 2001.

[Flores-HernandezJ1etal2002]

Jorge Flores-Hernandez, Carlos Cepeda, Elizabeth Hernandez-Echeagaray,

Christopher R Calvert, Eve S Jokel, Allen A Fienberg, Paul Greengard, and

Michael S Levine.

Dopamine enhancement of NMDA currents in dissociated medium-sized

striatal neurons: role of D1 receptors and DARPP-32.

J Neurophysiol, 88:3010-20, 2002.

[GaoWJetal2001]

W J Gao, L S Krimer, and P S Goldman-Rakic.

Presynaptic regulation of recurrent excitation by D1 receptors in

prefrontal circuits.

Proc Natl Acad Sci U S A, 98:295-300, 2001.

[GardnerBetal2001]

B Gardner, Z F Liu, D Jiang, and D R Sibley.

The role of phosphorylation/dephosphorylation in agonist-induced

desensitization of D1 dopamine receptor function: evidence for a novel

pathway for receptor dephosphorylation.

Mol Pharmacol, 59:310-21, 2001.[GeurtsMetal2002]

Muriel Geurts, Emmanuel Hermans, and Jean Marie Maloteaux.

Opposite modulation of regulators of G protein signalling-2 (RGS2)

and RGS4 expression by dopamine receptors in the rat striatum.

Neurosci Lett, pages 146-50, 2002.

[GoldmanMSetal2001]

M S Goldman, J Golowasch, E Marder, and L F Abbott.

Global structure, robustness, and modulation of neuronal models.

J Neurosci, 21:5229-38, 2001.

[Gonzalez-IslasHablitz2001]

C Gonzalez-Islas and J J Hablitz.

Dopamine inhibition of evoked IPSCs in rat prefrontal cortex.

J Neurophysiol, 86:2911-8, 2001.

[GrotewielSanders-Bush99]

M S Grotewiel and E Sanders-Bush.

Differences in agonist-independent activity of 5-Ht2A and 5-HT2c

receptors revealed by heterologous expression.

Naunyn Schmiedebergs Arch Pharmacol, 359:21-7, 1999.

[GurevichEVetal2001]

E V Gurevich, R T Robertson, and J N Joyce.

Thalamo-cortical afferents control transient expression of the

dopamine D(3) receptor in the rat somatosensory cortex.

Cereb Cortex, 11:691-701, 2001.

[HagaKetal97]

K Haga, H Tsuga, and T Haga.

Ca2+-dependent inhibition of G protein-coupled receptor kinase 2 by

calmodulin.

Biochemistry, 36:1315-21, 1997.

[HarveyLacey96]

J Harvey and M G Lacey.

Endogenous and exogenous dopamine depress EPSCs in rat nucleus

accumbens in vitro via D1 receptors activation.

J Physiol, 492:143-54, 1996.

[HausdorffWPetal90]

W P Hausdorff, M J Lohse, M Bouvier, S B Liggett, M G Caron, and R J Lefkowitz.

Two kinases mediate agonist-dependent phosphorylation and

desensitization of the beta 2-adrenergic receptor.

Symp Soc Exp Biol, 44:225-40, 1990.

[HenryDJetal98]

D J Henry, X T Hu, and F J White.

Adaptations in the mesoaccumbens dopamine system resulting from

repeated administration of dopamine D1 and D2 receptor-selective agonists:

relevance to cocaine sensitization.

Psychopharmacology (Berl), 140:233-42, 1998.

[HenryWhite95]

D J Henry and F J White.

The persistence of behavioral sensitization to cocaine parallels

enhanced inhibition of nucleus accumbens neurons.

J Neurosci, 15:6287-99, 1995.

[Hernandez-LopezSetal97]

S Hernandez-Lopez, J Bargas, D J Surmeier, A Reyes, and E Galarraga.

D1 receptor activation enhances evoked discharge in neostriatal

medium spiny neurons by modulating an L-type Ca2+ conductance.

J Neurosci, 17:3334-42, 1997.

[HsuKS96]

K S Hsu.

Characterization of dopamine receptors mediating inhibition of

excitatory synaptic transmission in the rat hippocampal slice.

J Neurophysiol, 76:1887-95, 1996.

[HsuKSetal95]

K S Hsu, C C Huang, C H Yang, and P W Gean.

Presynaptic D2 dopaminergic receptors mediate inhibition of

excitatory synaptic transmission in rat neostriatum.

Brain Res, 690:264-8, 1995.

[HuXTetal2002]

Xiu-Ti Hu, Timothy E Koeltzow, Donald C Cooper, George S Robertson, Francis J

White, and Paul Vezina.

Repeated ventral tegmental area amphetamine administration alters

dopamine D1 receptor signaling in the nucleus accumbens.

Synapse, 45:159-70, 2002.

[JakabGoldman-Rakic2000]

R L Jakab and P S Goldman-Rakic.

Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory

circuits of the primate cerebral cortex.

J Comp Neurol, 417:337-48, 2000.

[JeongIkeda2000]

S W Jeong and S R Ikeda.

Endogenous regulator of G-protein signaling proteins modify N-type

calcium channel modulation in rat sympathetic neurons.

J Neurosci, 20:4489-96, 2000.

[JeongIkeda2001]

S W Jeong and S R Ikeda.

Differential regulation of G protein-gated inwardly rectifying K(+)

channel kinetics by distinct domains of RGS8.

J Physiol, 535:335-47, 2001.

[JiangSibley99]

D Jiang and D R Sibley.

Regulation of D(1) dopamine receptors with mutations of protein

kinase phosphorylation sites: attenuation of the rate of agonist-induced

desensitization.

Mol Pharmacol, 56:675-83, 1999.

[KabbaniNetal2002]

Nadine Kabbani, Laszlo Negyessy, Ridwan Lin, Patricia Goldman-Rakic, and Robert

Levenson.

Interaction with neuronal calcium sensor NCS-1 mediates

desensitization of the D2 dopamine receptor.

J Neurosci, 22:8476-86, 2002.

[KassackMUetal2002]

Matthias U Kassack, Barbara Hofgen, Jochen Lehmann, Niels Eckstein, J Mark

Quillan, and Wolfgang Sadee.

Functional screening of G protein-coupled receptors by measuring

intracellular calcium with a fluorescence microplate reader.

J Biomol Screen, 7:233-46, 2002.

[KimDSetal2000]

D S Kim, M S Szczypka, and R D Palmiter.

Dopamine-deficient mice are hypersensitive to dopamine receptor

agonists.

J Neurosci, 20:4405-13, 2000.

[Koch99]

C Koch.

Biophysics of Computation:Information Processing in Single

Neurons .

\newblock Oxford University Press, 1999.

[KogaMomiyama2000]

E Koga and T Momiyama.

Presynaptic dopamine D2-like receptors inhibit excitatory

transmission onto rat ventral tegmental dopaminergic neurones.

J Physiol, 523:163-73, 2000.

[Konenetal94]

W Konen, T Maurer, and C von der Malsburg.

A fast dynamic link mathing algorithm for invariant pattern

recognition.

Neural Networks, 7:1019-1030, 1994.

[KraselCetal2001]

C Krasel, S Dammeier, R Winstel, J Brockmann, H Mischak, and M J Lohse.

Phosphorylation of GRK2 by protein kinase C abolishes its inhibition

by calmodulin.

J Biol Chem, 276:1911-5, 2001.

[KrupnickBenovic98]

J G Krupnick and J L Benovic.

The role of receptor kinases and arrestins in G protein-coupled

receptor regulation.

Annu Rev Pharmacol Toxicol, 38:289-319, 1998.

[LameyMetal2002]

Michael Lamey, Miles Thompson, George Varghese, Hong Chi, Marek Sawzdargo,

Susan R George, and Brian F O'Dowd.

Distinct residues in the carboxyl tail mediate agonist-induced

desensitization and internalization of the human dopamine D1 receptor.

J Biol Chem, 277:9415-21, 2002.

[LanfumeyLetal99]

L Lanfumey, M C Pardon, N Laaris, C Joubert, N Hanoun, M Hamon, and

C Cohen-Salmon.

5-HT1A autoreceptor desensitization by chronic ultramild stress in

mice.

Neuroreport, 10:3369-74, 1999.

[LaruelleMetal97]

M Laruelle, C D D'Souza, R M Baldwin, A Abi-Dargham, S J Kanes, C L Fingado,

J P Seibyl, S S Zoghbi, M B Bowers, P Jatlow, D S Charney, and R B Innis.

Imaging D2 receptor occupancy by endogenous dopamine in humans.

Neuropsychopharmacology, 17:162-74, 1997.

[Law-ThoDetal94]

D Law-Tho, J C Hirsch, and F Crepel.

Dopamine modulation of synaptic transmission in rat prefrontal

cortex: an in vitro electrophysiological study.

Neurosci Res, 21:151-60, 1994.

[LetchworthSRetal2001]

S R Letchworth, M A Nader, H R Smith, D P Friedman, and L J Porrino.

Progression of changes in dopamine transporter binding site density

as a result of cocaine self-administration in rhesus monkeys.

J Neurosci, 21:2799-807, 2001.

[LewisMMetal98]

M M Lewis, V J Watts, C P Lawler, D E Nichols, and R B Mailman.

Homologous desensitization of the D1A dopamine receptor: efficacy in

causing desensitization dissociates from both receptor occupancy and

functional potency.[LinRetal2001]

R Lin, K Karpa, N Kabbani, P Goldman-Rakic, and R Levenson.

Dopamine D2 and D3 receptors are linked to the actin cytoskeleton

via interaction with filamin A.

Proc Natl Acad Sci U S A, 98:5258-63, 2001.

[LiuYetal99]

Y Liu, D E Krantz, C Waites, and R H Edwards.

Membrane trafficking of neurotransmitter transporters in the

regulation of synaptic transmission.

Trends Cell Biol, 9:356-63, 1999.

[LohseMJetal90]

M J Lohse, J L Benovic, J Codina, M G Caron, and R J Lefkowitz.

beta-Arrestin: a protein that regulates beta-adrenergic receptor

function.

Science, 248:1547-50, 1990.

[Magee2003]

Jeffrey C Magee.

A prominent role for intrinsic neuronal properties in temporal

coding.

Trends Neurosci, 26:14-6, 2003.

[Manahan-VaughanKulla2003]

Denise Manahan-Vaughan and Alexander Kulla.

Regulation of Depotentiation and Long-term Potentiation in the

Dentate Gyrus of Freely Moving Rats by Dopamine D2-like Receptors.

Cereb Cortex, 13:123-35, 2003.

[MarderEetal96]

E Marder, L F Abbott, G G Turrigiano, Z Liu, and J Golowasch.

Memory from the dynamics of intrinsic membrane currents.

Proc Natl Acad Sci U S A, 93:13481-6, 1996.

[MasonJNetal2002]

John N Mason, Laura B Kozell, and Kim A Neve.

Regulation of dopamine D(1) receptor trafficking by protein kinase

A-dependent phosphorylation.

Mol Pharmacol, 61:806-16, 2002.

[MauriceNetal2001]

N Maurice, T Tkatch, M Meisler, L K Sprunger, and D J Surmeier.

D1/D5 dopamine receptor activation differentially modulates rapidly

inactivating and persistent sodium currents in prefrontal cortex pyramidal

neurons.

J Neurosci, 21:2268-77, 2001.

[MayfieldRDetal92]

R D Mayfield, G Larson, and N R Zahniser.

Cocaine-induced behavioral sensitization and D1 dopamine receptor

function in rat nucleus accumbens and striatum.

Brain Res, 573:331-5, 1992.

[MengSZetal99]

S Z Meng, Y Ozawa, M Itoh, and S Takashima.

Developmental and age-related changes of dopamine transporter, and

dopamine D1 and D2 receptors in human basal ganglia.

Brain Res, 843:136-44, 1999.

[MoisesSmith89]

H C Moises and C B Smith.

Electrophysiological responsiveness to isoproterenol in rat

hippocampal slices correlates with changes in beta-adrenergic receptor

density induced by chronic morphine treatment.

Brain Res, 485:67-78, 1989.

[MomiyamaKoga2001]

T Momiyama and E Koga.

Dopamine D(2)-like receptors selectively block N-type Ca(2+)

channels to reduce GABA release onto rat striatal cholinergic interneurones.

J Physiol, 533:479-92, 2001.

[MomiyamaSim96]

T Momiyama and J A Sim.

Modulation of inhibitory transmission by dopamine in rat basal

forebrain nuclei: activation of presynaptic D1-like dopaminergic receptors.

J Neurosci, 16:7505-12, 1996.

[MontagueDMetal99]

D M Montague, C P Lawler, R B Mailman, and J H Gilmore.

Developmental regulation of the dopamine D1 receptor in human

caudate and putamen.

Neuropsychopharmacology, 21:641-9, 1999.

[MorganDetal2002]

Drake Morgan, Kathleen A Grant, H Donald Gage, Robert H Mach, Jay R Kaplan,

Osric Prioleau, Susan H Nader, Nancy Buchheimer, Richard L Ehrenkaufer, and

Michael A Nader.

Social dominance in monkeys: dopamine D2 receptors and cocaine

self-administration.

Nat Neurosci, 5:169-74, 2002.

[MorrisonKJetal96]

K J Morrison, R H Moore, N D Carsrud, J Trial, E E Millman, M Tuvim, R B Clark,

R Barber, B F Dickey, and B J Knoll.

Repetitive endocytosis and recycling of the beta 2-adrenergic

receptor during agonist-induced steady state redistribution.

Mol Pharmacol, 50:692-9, 1996.[NestlerAghajanian97]

E J Nestler and G K Aghajanian.

Molecular and cellular basis of addiction.

Science, 278:58-63, 1997.

[NgGYetal94]

G Y Ng, B Mouillac, S R George, M Caron, M Dennis, M Bouvier, and B F O'Dowd.

Desensitization, phosphorylation and palmitoylation of the human

dopamine D1 receptor.

Eur J Pharmacol, 267:7-19, 1994.

[NgGYetal95]

G Y Ng, J Trogadis, J Stevens, M Bouvier, B F O'Dowd, and S R George.

Agonist-induced desensitization of dopamine D1 receptor-stimulated

adenylyl cyclase activity is temporally and biochemically separated from D1

receptor internalization.

Proc Natl Acad Sci U S A, 92:10157-61, 1995.

[NgGYetal97]

G Y Ng, G Varghese, H T Chung, J Trogadis, P Seeman, B F O'Dowd, and S R

George.

Resistance of the dopamine D2L receptor to desensitization

accompanies the up-regulation of receptors on to the surface of Sf9 cells.

Endocrinology, 138:4199-206, 1997.

[NicolaSMetal96]

S M Nicola, S B Kombian, and R C Malenka.

Psychostimulants depress excitatory synaptic transmission in the

nucleus accumbens via presynaptic D1-like dopamine receptors.

J Neurosci, 16:1591-604, 1996.

[NicolaMalenka97]

S M Nicola and R C Malenka.

Dopamine depresses excitatory and inhibitory synaptic transmission

by distinct mechanisms in the nucleus accumbens.

J Neurosci, 17:5697-710, 1997.

[NicolaSMetal2000]

S M Nicola, J Surmeier, and R C Malenka.

Dopaminergic modulation of neuronal excitability in the striatum and

nucleus accumbens.

Annu Rev Neurosci, 23:185-215, 2000.

[OrtegaAetal96]

A Ortega, M A del Guante, R A Prado-Alcala, and V Aleman.

Changes in rat brain muscarinic receptors after inhibitory avoidance

learning.

Life Sci, 58:799-809, 1996.

[PisaniAetal2000]

A Pisani, P Bonsi, D Centonze, P Calabresi, and G Bernardi.

Activation of D2-like dopamine receptors reduces synaptic inputs to

striatal cholinergic interneurons.

J Neurosci, 20:RC69, 2000.

[PowerJMetal2002]

John M Power, Wendy W Wu, Evgeny Sametsky, M Mathew Oh, and John F Disterhoft.

Age-related enhancement of the slow outward calcium-activated

potassium current in hippocampal CA1 pyramidal neurons in vitro.

J Neurosci, 22:7234-43, 2002.

[ProninANetal97]

A N Pronin, D K Satpaev, V Z Slepak, and J L Benovic.

Regulation of G protein-coupled receptor kinases by calmodulin and

localization of the calmodulin binding domain.

J Biol Chem, 272:18273-80, 1997.

[RoozendaalBetal97]

B Roozendaal, E A van der Zee, R A Hensbroek, H Maat, P G Luiten, J M Koolhaas,

and B Bohus.

Muscarinic acetylcholine receptor immunoreactivity in the

amygdala-II. Fear-induced plasticity.

Neuroscience, 76:75-83, 1997.

[SalinasSejnowski2001]

E Salinas and T J Sejnowski.

Gain modulation in the central nervous system: where behavior,

neurophysiology, and computation meet.

Neuroscientist, 7:430-40, 2001.

[SamamaPetal93]

P Samama, S Cotecchia, T Costa, and R J Lefkowitz.

A mutation-induced activated state of the beta 2-adrenergic

receptor. Extending the ternary complex model.

J Biol Chem, 268:4625-36, 1993.

[ScheggiSetal2002]

Simona Scheggi, Benedetta Leggio, Flavio Masi, Silvia Grappi, Carla Gambarana,

Giulio Nanni, Riccardo Rauggi, and Maria Graziella De Montis.

Selective modifications in the nucleus accumbens of dopamine

synaptic transmission in rats exposed to chronic stress.

J Neurochem, 83:895-903, 2002.

[IJCNN2003]

G Scheler and J M Schumann.

Presynaptic modulation as fast synaptic switching: state-depende nt

modulation of task performance.

Proceedings of the 2003 International Joint Conference on

Neural Networks (IJCNN 2003). IEEE Press, 2003.

[SchultzWetal97]

W Schultz, P Dayan, and R Montague.

The computational role of dopamine D1 receptors in working memory.

Neural Networks, 15:561-72, 2002.

[ScottLetal2002]

Lena Scott, Maria Sol Kruse, Hans Forssberg, Hjalmar Brismar, Paul Greengard,

and Anita Aperia.

Selective up-regulation of dopamine D1 receptors in dendritic spines

by NMDA receptor activation.

Proc Natl Acad Sci U S A, 99:1661-4, 2002.

[SeamansJKetal2001]

J K Seamans, D Durstewitz, B R Christie, C F Stevens, and T J Sejnowski.

Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to

layer V prefrontal cortex neurons.

Proc Natl Acad Sci U S A, 98:301-6, 2001.

[SeemanPetal2002]

Philip Seeman, Teresa Tallerico, Francoise Ko, Catherine Tenn, and Shitij

Kapur.

Amphetamine-sensitized animals show a marked increase in dopamine D2

high receptors occupied by endogenous dopamine, even in the absence of acute

challenges.

Synapse, 46:235-9, 2002.

[ShenJohnson2000]

K Z Shen and S W Johnson.

Presynaptic dopamine D2 and muscarine M3 receptors inhibit

excitatory and inhibitory transmission to rat subthalamic neurones in vitro.

J Physiol, 525:331-41, 2000.

[SibleyDRetal98]

D R Sibley, A L Ventura, D Jiang, and C Mak.

Regulation of the D1 dopamine receptor through cAMP-mediated

pathways.

Adv Pharmacol, 42:447-50, 1998.

[SidhuAetal99]

A Sidhu, B Olde, N Humblot, K Kimura, and N Gardner.

Regulation of human D1 dopamine receptor function and gene

expression in SK-N-MC neuroblastoma cells.

Neuroscience, 91:537-47, 1999.

[SnyderGLetal2000]

G L Snyder, P B Allen, A A Fienberg, C G Valle, R L Huganir, A C Nairn, and

P Greengard.

Regulation of phosphorylation of the GluR1 AMPA receptor in the

neostriatum by dopamine and psychostimulants in vivo.

J Neurosci, 20:4480-8, 2000.

[StenkampKetal98]

K Stenkamp, U Heinemann, and D Schmitz.

Dopamine suppresses stimulus-induced field potentials in layer III

of rat medial entorhinal cortex.

Neurosci Lett, 255:119-21, 1998.

[SurmeierDJetal95]

D J Surmeier, J Bargas, H C Jr Hemmings, A C Nairn, and P Greengard.

Modulation of calcium currents by a D1 dopaminergic protein

kinase/phosphatase cascade in rat neostriatal neurons.

Neuron, 14:385-97, 1995.

[SurmeierDJetal96]

D J Surmeier, W J Song, and Z Yan.

Coordinated expression of dopamine receptors in neostriatal medium

spiny neurons.

J Neurosci, 16:6579-91, 1996.

[TeicherMHetal95]

M H Teicher, S L Andersen, and J C Jr Hostetter.

Evidence for dopamine receptor pruning between adolescence and

adulthood in striatum but not nucleus accumbens.

Brain Res Dev Brain Res, 89:167-72, 1995.

[ThanosPKetal2001]

P K Thanos, N D Volkow, P Freimuth, H Umegaki, H Ikari, G Roth, D K Ingram, and

R Hitzemann.

Overexpression of dopamine D2 receptors reduces alcohol

self-administration.

J Neurochem, 78:1094-103, 2001.

[TiberiCaron94]

M Tiberi and M G Caron.

High agonist-independent activity is a distinguishing feature of the

dopamine D1B receptor subtype.

J Biol Chem, 269:27925-31, 1994.

[TiberiMetal96]

M Tiberi, S R Nash, L Bertrand, R J Lefkowitz, and M G Caron.

Differential regulation of dopamine D1A receptor responsiveness by

various G protein-coupled receptor kinases.

J Biol Chem, 271:3771-8, 1996.

[TsaovonZastrow2000]

P Tsao and M von Zastrow.

Downregulation of G protein-coupled receptors.

Curr Opin Neurobiol, 10:365-9, 2000.

[UnterwaldEMetal94]

E M Unterwald, A Ho, J M Rubenfeld, and M J Kreek.

Time course of the development of behavioral sensitization and

dopamine receptor up-regulation during binge cocaine administration.

J Pharmacol Exp Ther, 270:1387-96, 1994.

[UrbanNNetal2002]

Nathaniel N Urban, Guillermo Gonzalez-Burgos, Darrell A Henze, David A Lewis,

and German Barrionuevo.

Selective reduction by dopamine of excitatory synaptic inputs to

pyramidal neurons in primate prefrontal cortex.

J Physiol, 539:707-12, 2002.

[vanderZeeEAetal95]

E A Van der Zee, J C Compaan, B Bohus, and P G Luiten.

Alterations in the immunoreactivity for muscarinic acetylcholine

receptors and colocalized PKC gamma in mouse hippocampus induced by spatial

discrimination learning.

Hippocampus, 5:349-62, 1995.

[vanderZeeEAetal94]

E A Van der Zee, B R Douma, B Bohus, and P G Luiten.

Passive avoidance training induces enhanced levels of

immunoreactivity for muscarinic acetylcholine receptor and coexpressed PKC

gamma and MAP-2 in rat cortical neurons.

Cereb Cortex, 4:376-90, 1994.

[vanderZeeLuiten99]

E A van der Zee and P G Luiten.

Muscarinic acetylcholine receptors in the hippocampus, neocortex and

amygdala: a review of immunocytochemical localization in relation to learning

and memory.

Prog Neurobiol, 58:409-71, 1999.

[vanderZeeEAetal97]

E A van der Zee, B Roozendaal, B Bohus, J M Koolhaas, and P G Luiten.

Muscarinic acetylcholine receptor immunoreactivity in the

amygdala-I. Cellular distribution correlated with fear-induced behavior.

Neuroscience, 76:63-73, 1997.

[VenturaSibley2000]

A L Ventura and D R Sibley.

Altered regulation of the D(1) dopamine receptor in mutant Chinese

hamster ovary cells deficient in cyclic AMP-dependent protein kinase

activity.

J Pharmacol Exp Ther, 293:426-34, 2000.[Verhoeff99]

N P Verhoeff.

Radiotracer imaging of dopaminergic transmission in neuropsychiatric

disorders.

Psychopharmacology (Berl), 147:217-49, 1999.

[VickeryvonZastrow99]

R G Vickery and M von Zastrow.

Distinct dynamin-dependent and -independent mechanisms target

structurally homologous dopamine receptors to different endocytic membranes.

J Cell Biol, 144:31-43, 1999.

[VittenIsaacson2001]

H Vitten and J S Isaacson.

Synaptic transmission: exciting times for presynaptic receptors.

Curr Biol, 11:R695-7, 2001.

[vonZastrowMostov2001]

M von Zastrow and K Mostov.

Signal transduction. A new thread in an intricate web.

Science, 294:1845-7, 2001.

[WangODonnell2001]

J Wang and P O'Donnell.

D(1) dopamine receptors potentiate nmda-mediated excitability

increase in layer V prefrontal cortical pyramidal neurons.

Cereb Cortex, 11:452-62, 2001.

[WangWetal96]

W Wang, K H Hahn, J F Bishop, D Q Gao, P A Jose, and M M Mouradian.

Up-regulation of D3 dopamine receptor mRNA by neuroleptics.

Synapse, 23:232-5, 1996.

[WangZetal2002]

Z Wang, X Q Feng, and P Zheng.

Activation of presynaptic D1 dopamine receptors by dopamine

increases the frequency of spontaneous excitatory postsynaptic currents

through protein kinase A and protein kinase C in pyramidal cells of rat

prelimbic cortex.

Neuroscience, 112:499-508, 2002.

[YungBolam2000]

K K Yung and J P Bolam.

Localization of dopamine D1 and D2 receptors in the rat neostriatum:

synaptic interaction with glutamate- and GABA-containing axonal terminals.

Synapse, 38:413-20, 2000.

[ZahniserNRetal86]

N R Zahniser, G R Weiner, T Worth, K Philpott, R P Yasuda, G Jonsson, and T V

Dunwiddie.

DSP4-induced noradrenergic lesions increase beta-adrenergic

receptors and hippocampal electrophysiological responsiveness.

Pharmacol Biochem Behav, 24:1397-402, 1986.

[ZhangXFetal2002]

Xu-Feng Zhang, Donald C Cooper, and Francis J White.

Repeated cocaine treatment decreases whole-cell calcium current in

rat nucleus accumbens neurons.

J Pharmacol Exp Ther, 301:1119-25, 2002.

[ZhengBetal2001]

B Zheng, Y C Ma, R S Ostrom, C Lavoie, G N Gill, P A Insel, X Y Huang, and M G

Farquhar.

RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular

trafficking.

Science, 294:1939-42, 2001.

Prog Biophys Mol Biol, 81:45-65, 2003

Metadata

Repository Staff Only: item control page

Cogprints is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.