Cogprints

Susceptibility of conjunctival bacterial pathogens to fluoroquinolones. A comparative study of ciprofloxacin, norfloxacin and ofloxacin

Faustina, Dr Idu and Odjimogho, Ms Stella (2003) Susceptibility of conjunctival bacterial pathogens to fluoroquinolones. A comparative study of ciprofloxacin, norfloxacin and ofloxacin. [Journal (On-line/Unpaginated)]

Full text available as:

[img]
Preview
 PDF
179Kb

Abstract

In order to determine the most common bacteria implicated in conjunctivitis, and the effectiveness of the antibiotic Fluoroquinolone for its treatment, a total of 50 subjects (100 ) eyes, between the ages of 1-30 years with mean age of 16.94 ± 8.06 years with infected eyes, were examined at the Lagos State University Teaching Hospital, Nigeria (LASUTH). Conjunctival swabs were collected and cultured in the laboratory to isolate the pathogens responsible for the infection. Sensitivity and antibiotic suscepticibility tests were carried out with discs impregnated with 0.3% concentration of ophthalmic topical solutions of chibroxin (Norfloxacin), ciloxan (Ciprofloxacin), and ocuflox (Ofloxacin), to ascertain the most sensitive of the three drugs. The results showed that the implicated bacteria in order of decreasing frequency were Staphylococcus aureus (34%), followed by Streptococcus pneumoniae (22%), Pseudomonas aeruginosa (14%), Klebsiella pneumoniae (12%), Hemophilus influenzae (9%), Escherichia coli (9%). All the isolated organisms were highly sensitive to the three drugs. However, a one way analysis of variance (ANOVA) showed a significant difference in the sensitivity of the three drugs (p< 0.05). ANOVA Post Hoc located Ciprofloxacin as the source of the significance. In conclusion therefore, Ciprofloxacin is the most sensitive of the three drugs and, hence should be the first choice of the fluoroquinolones for the treatment of bacterial conjunctivitis.

Item Type:Journal (On-line/Unpaginated)
Keywords:Conjunctivitis, fluoroquinolones
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:3236
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:18 Oct 2003
Last Modified:11 Mar 2011 08:55

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Vaughan D, Asbury T and Riodan-Eva P. General Ophthalmology, Lange Medical publication, 15th ed. 1996; PP 96-67.

2. Kanski JJ. Clinical Ophthalmology. 3rd ed. Butterworth-Heinemann-Int’l ed. Woburn, MA; 1998.p. 514.

3. Yetman R and Coody D. Conjunctivitis: A practice guideline. J Pediatric HealthCare. 1997;11(5):238-44

4. Wolfson, JS and Hooper DC. The fluoroquinolones: structure, mechanism of action and resistance and spectra of activity in vitro. Antimicrobe Agent chemother. 1985; Pp 28,58.

5. Brower, K., Kowalski, R and Gordon M. Flouroquinolones in the treatment of bacteria keratitis Am J Ophthalmol 1996; 121:712-5.

6. Lu, KL Prajna, NV and Macdonell, PJ. Comparism of Ofloxacin and Ciprofloxacin in the therapy of bacteria keratitis. Invest Ophthalmol Vis Sci 1998; 39:5140.

7. O’brian, TP, Maguire, MG, Fink, NE, Alfonso E and Mcdonnell P. For the bacterial keratitis study group. Efficacy of ofloxacin vs Cefazolin and Tobramycin in the therapy of bacterial keratitis. Arc ophthalmol. 1995; 113:1257-65.

8. Jauch, A. et al Meta analysis of six clinical phase III studies comparing 0.3% lomefloxacin twice daily with five standard antibiotics in patients with acute bacterial conjunctivitis. Graefs Arch Clin Exp Ophthalmol. 1999; In press.

9. Baum, JL. Bacterial conjunctivitis: Diagnosis and Treatment. APUA Newsletter. 1997; 15(4): 1, 4-5, 8.

10. Haesaert, PS. Clinical manual of ocular microbiology and cytology, Mosby year book. 1993; pp 30-32, 68, 102, 114-115.

11. Prescott LM, Harley JP and Klein DA. Microbiology. 4th ed. McGraw-Hills Co, U.S.A; 1999. p. 780.

Metadata

Repository Staff Only: item control page

Cogprints is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.