Cogprints

Odor Based Behavioral Tasks Confounded by Distance Dependent Detection: Modification of a Murine Digging Paradigm

KATZ, EMILY and ROTHSCHILD, OLIVER and HERRERA, ANDRIANA and HUANG, SOFIA and WONG, ANNA and WOJCIECHOWSKI, YVETTE and GIL, AIDA and YAN, QI JIANG and BAUCHWITZ, ROBERT (2003) Odor Based Behavioral Tasks Confounded by Distance Dependent Detection: Modification of a Murine Digging Paradigm. [Preprint]

Full text available as:

[img]
Preview
 PDF
260Kb

Abstract

Tests of murine higher order cognition are important in order to fully explore the effects of genetic alterations and potential therapies in models of human mental retardation and other deficits of intellect. In this study, inbred and F1 hybrid strains of mice were assessed in a five odor sequence task previously described for rats which employs buried food rewards. Data are provided indicating that the use of buried rewards in mouse olfactory digging tasks should be approached with significant caution. An alternate test of sequence dependent working memory (2-sequence task) using a post choice, drop-in food reward is described. After achievement of stable average plateau scores, a streak and slump pattern, rather than near errorless performance, was observed. Therefore, mice do not appear to effortlessly acquire sequences of odors in a working memory paradigm in which rewarded odors are constantly changing.

Item Type:Preprint
Keywords:sequence memory, learning set, olfactory discrimination, digging tasks, episodic memory, Murine Olfactory Sequence Tasks, mouse, rat, rodent
Subjects:Biology > Animal Cognition
ID Code:3316
Deposited By: Bauchwitz, Robert
Deposited On:16 Dec 2003
Last Modified:11 Mar 2011 08:55

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

Artal, P., Herreros de Tejada, P., Munoz Tedo, C., & Green, D. G. (1998). Retinal image quality in the rodent eye. Vis Neurosci, 15(4), 597-605.

Berger-Sweeney, J., Libbey, M., Arters, J., Junagadhwalla, M., & Hohmann, C. F. (1998). Neonatal monoaminergic depletion in mice (Mus musculus) improves performance of a novel odor discrimination task. Behav Neurosci, 112(6), 1318-1326.

Bodyak, N., & Slotnick, B. (1999). Performance of mice in an automated olfactometer: odor detection, discrimination and odor memory. Chem Senses, 24(6), 637-645.

Bunsey, M., & Eichenbaum, H. (1996). Conservation of hippocampal memory function in rats and humans. Nature, 379(6562), 255-257.

Crusio, W. E., Schwegler, H., & Brust, I. (1993). Covariations between hippocampal mossy fibres and working and reference memory in spatial and non-spatial radial maze tasks in mice. Eur J Neurosci, 5(10), 1413-1420.

Dusek, J. A., & Eichenbaum, H. (1997). The hippocampus and memory for orderly stimulus relations. Proc Natl Acad Sci U S A, 94(13), 7109-7114.

Dykens, E. M., Hodapp, R. M., & Leckman, J. F. (1987). Strengths and weaknesses in the intellectual functioning of males with fragile X syndrome. Am J Ment Defic, 92(2), 234-236.

Fortin, N. J., Agster, K. L., & Eichenbaum, H. B. (2002). Critical role of the hippocampus in memory for sequences of events. Nat Neurosci, 5(5), 458-462.

Hodapp, R. M., Leckman, J. F., Dykens, E. M., Sparrow, S. S., Zelinsky, D. G., & Ort, S. I. (1992). K-ABC profiles in children with fragile X syndrome, Down syndrome, and nonspecific mental retardation. Am J Ment Retard, 97(1), 39-46.

Jennings, J. W., & Keefer, L. H. (1969). Olfactory learning set in two varieties of domestic rat. Psychol Rep, 24(1), 3-15.

Kemper, M. B., Hagerman, R. J., & Altshul-Stark, D. (1988). Cognitive profiles of boys with the fragile X syndrome. Am J Med Genet, 30(1-2), 191-200.

Kesner, R. P., Gilbert, P. E., & Barua, L. A. (2002). The role of the hippocampus in memory for the temporal order of a sequence of odors. Behav Neurosci, 116(2), 286-290.

McIlvane, W. J., & Cataldo, M. F. (1996). On the clinical relevance of animal models for the study of human mental retardation. Mental Retardation and Developmental Disabilities Research Reviews, 2, 188-196.

Mihalick, S. M., Langlois, J. C., Krienke, J. D., & Dube, W. V. (2000). An olfactory discrimination procedure for mice. J Exp Anal Behav, 73(3), 305-318.

Nigrosh, B. J., Slotnick, B. M., & Nevin, J. A. (1975). Olfactory discrimination, reversal learning, and stimulus control in rats. J Comp Physiol Psychol, 89(4), 285-294.

Reid, I. C., & Morris, R. G. (1993). The enigma of olfactory learning. Trends Neurosci, 16(1), 17-20.

Schellinck, H. M., Forestell, C. A., & LoLordo, V. M. (2001). A simple and reliable test of olfactory learning and memory in mice. Chem Senses, 26(6), 663-672.

Slotnick, B. (2001). Animal cognition and the rat olfactory system. Trends Cogn Sci, 5(5), 216-222.

Slotnick, B., Hanford, L., & Hodos, W. (2000). Can rats acquire an olfactory learning set? J Exp Psychol Anim Behav Process, 26(4), 399-415.

Slotnick, B. M. (1994). The enigma of olfactory learning revisited. Neuroscience, 58(1), 1-12.

Strupp, B. J., & Levitsky, D. A. (1990). An animal model of retarded cognitive development. Adv Infancy Res, 6, 149-185.

Warren, J. M. (1973). Learning in Vertebrates. In D. A. Rethlingshafer (Ed.), Comparative psychology: a modern survey (pp. 471-509). New York: McGraw-Hill.

Yan, Q., Asafo-Adjei, P. K., Arnold, H. M., Brown, R. E., & Bauchwitz, R. (2003). A Phenotypic and Molecular Characterization of the fmr1-tm1Cgr Fragile X Mouse. Genes Brain Behav, in revision.

Zagreda, L., Goodman, J., Druin, D. P., McDonald, D., & Diamond, A. (1999). Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation. J Neurosci, 19(14), 6175-6182.

Metadata

Repository Staff Only: item control page

Cogprints is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.