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Brugada Syndrome: The Syndrome of Right Bundle Branch Block, ST segment Elevation in V1 to V3 and Sudden Death

Brugada, Josep and Brugada, Pedro and Brugada, Ramon (2001) Brugada Syndrome: The Syndrome of Right Bundle Branch Block, ST segment Elevation in V1 to V3 and Sudden Death. [Journal (Paginated)]

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Abstract

In 1992 a new syndrome consisting of syncopal episodes and/or sudden death in patients with a structurally normal heart and a characteristic electrocardiogram (ECG) with a pattern of right bundle branch block with an ST segment elevation in leads V1 to V3 was described 1 In 1998 the poor prognosis of patients with the syndrome not receiving an implantable defibrillator was reported 2,3 In 1998 the genetic nature of the disease and its assotiation to a mutation in the cardiac sodium channel gene was described 4 . Because the diagnosis is easily made by means of the ECG, an increasing number of patients with the ECG pattern are being identified worldwide. In this article we will review our present knowledge concerning patients with the classical ECG pattern of the disease.

Item Type:Journal (Paginated)
Keywords:Right Bundle Branch Block; ST segment Elevation in V1 to V3; Sudden Death
Subjects:JOURNALS > Indian Pacing and Electrophysiology Journal
ID Code:4328
Deposited By: Indian Pacing and Electrophysiology, Journal
Deposited On:02 May 2005
Last Modified:11 Mar 2011 08:56

References in Article

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1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391-1396. Medline

2. Brugada J, Brugada R, Brugada P. Right bundle branch block and ST segment elevation in leads V1-V3: A marker for sudden death in patients with no demonstrable structural heart disease. Circulation 1998;97:457-460. Medline

3. Nademanee K, Veerakul G, Nimmannit S, et al. Arrhythmogenic marker for the sudden unexplained death syndrome in Thai men. Circulation 1997;96:2595-2600. Medline

4. Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, et al. Genetic basis and molecular mechanisms for idiopathic ventricular fibrillation. Nature; 1998;392:293-296. Medline

5. Tohyou Y, Nakazawa K Ozawa A, et al. A survey in the incidence of right bundle branch block with ST segment elevation among normal population. Jpn J Electrocardiol 1995;15:223-226. (No Abstract Available)

6. Namiki T, Ogura T, Kuwabara Y, et al. Five-year mortality and clinical characteristics of adult subjects with right bundle branch block and ST elevation. Circulation 1995;93:334. Medline

7. Hata Y, Chiba N, Hotta K, et al. Incidence and clinical significance of right bundle branch block and ST segment elevation in V1-V3 in 6-to 18-year-old school children in Japan. Circulation 1997;20:2310. (No Abstract Available)

8. Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S. Autonomic and antiarrhythmic modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 1996;27:1061-1070. Medline

9. Antzelevitch C: The Brugada syndrome. J Cardiovasc Electrophysiol 1998;9:513-516. (No Abstract Available)

10. Gussak I, Antzelevitch C, Bjerregaard P, Towbin JA, Chaitman BR. The Brugada syndrome. Clinical, electrophysiologic and genetic aspects. J Am Coll Cardiol 1999;33:5-15. Medline

11. Priori SG, Diehl L, Schwartz PJ. Torsade de pointes. In: Podrid PJ, Kowey PR, eds. Cardiac Arrhythmia. Williams and Wilkins, Baltimore 1995, p 951-963.

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