A theory of general impairment of gene-expression manifesting as autism

Clarke, R.P. (1993) A theory of general impairment of gene-expression manifesting as autism. [Journal (Paginated)]


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This is the first part of a combined theory of autism and general intelligence (IQ). It is argued that general impairment of gene-expression, produced by a diversity of environmental and genetic causes, is in moderation advantageous in suppressing genetic idiosyncracies. But in excess it will produce a condition involving abnormalities of appearance and behaviour, with a particular relationship to high parental social class and IQ and with particular sex distributions. Character-istics and findings relating to schizophrenia, manic-depressive illness, or neuroses indicate that they cannot reasonably be considered manifestations of excessive general impairment of gene-expression. By contrast, characteristics and findings relating to autism accord very well with this conception. The suggestion is that autism involves primary abnormalities in diverse parts of the brain and in diverse psychological functions. Random binding to DNA may be a substantial mechanism of general impairment of gene-expression. [i.e., would definitely cause impairment, and hence cause autism, but only may be substantially involved (see para. 15)].

Item Type:Journal (Paginated)
Additional Information:A paper giving update information relating to this paper, confirming three predictions and providing resolution of the later autism increase controversy is in preparation, so this otherwise difficult-to-access document needs to be more accessible!
Keywords:autism intelligence iq autistic asperger theory cause gene-expression mercury
Subjects:Psychology > Developmental Psychology
Biology > Behavioral Biology
Psychology > Clinical Psychology
ID Code:4664
Deposited By: Clarke, Robin Philip
Deposited On:30 Dec 2005
Last Modified:11 Mar 2011 08:56

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