Evolving clinical profile of HLA-DRB1, MMP1 and NF-Κb gene in rheumatoid factor positive Caucasian population

Anupama Sharma, Ajay kumar Singh, Sanjeev kumar Singh, Neelima Singh, Varsha Gupta Int J Cur Sci Res. (2011) Evolving clinical profile of HLA-DRB1, MMP1 and NF-Κb gene in rheumatoid factor positive Caucasian population. [Journal (Paginated)]

Full text available as:

PDF (Evolving clinical profile of HLA-DRB1, MMP1 and NF-Κb gene in rheumatoid factor positive Caucasian population ) - Published Version
Available under License Creative Commons Attribution No Derivatives.



Rheumatoid arthritis (RA), a systemic autoimmune condition, causes joint damage and sometimes extra-articular lesions (cutaneous vasculitis, neuropathy, Felty’s syndrome, pericarditis, intersticial lung disease) that may be life threatening. The reason why extra-articular features will develop in rare RA patients is unknown. Our study was aimed to find any disease correlation with respect to a few genetic loci implicated in rheumatoid arthritis. In our study no significant association was observed for NFkB1 and MMP-1. However HLA-DRB1 showed polymorphism in RA and controls. The study was conducted on 60 patients, where 30 were control and 30 were diseased. All the patients selected for the study were RF (rheumatoid factor) positive. Therefore the studies need to be conducted on larger group of patients, so that the association can be verified in Caucasian population (Indian scenario).

Item Type:Journal (Paginated)
Keywords:Rheumatoid arthritis, Rheumatoid factor, HLA-DRB1, MMP1, NFkB1.
ID Code:7305
Deposited By: CurrentSciDirect Publications, International Journal of Current Scientific Research (IJCSR)
Deposited On:02 May 2011 15:53
Last Modified:02 May 2011 15:53

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

[1] Arnett FC, Edworthy SM, Bloch DA. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31:315–24.

[2] O Dell JR. Therapeutic Strategies for Rheumatoid Arthritis. N Engl J Med, 2004; 350:2591-2602.

[3] Newton JL, Harney S M J, Wordsworth BP, Brown MA. A review of the MHC genetics of rheumatoid arthritis. Genes Immun. 2004; 5:151–157.

[4] Gay S, Gay RE, Koopman WJ. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? Ann Rheum Dis. 1993; 52 Suppl 1:39-47.

[5] Spurr NK, Gough AC, Gosden J, Rout D, Proteous DJ, Van H V, Docherty AJ. Restriction fragment length polymorohism analysis and assignment of the metalloptoteinase stromelysin and collagenase to the long arm of chromosome 11. Genomics. 1988; 2: 119-127.

[6] Rutter JL, Mitchell TI, Buttice G, Meyers J, Gusella JF, Ozelius LJ, Brinckerhoff CE. A single nucleotide polymorphism in the MMP 1 promoter creates an Ets binding site and augments transcription. Cancer Res. 1998; 58:5321-5325.

[7] Ghilardi G, Biondi M L, Mangoni J. Matrix Metalloproteinase 1 Promoter Polymorphism 1G/2G Is Correlated with Colorectal Cancer Invasiveness. Clin Cancer Res. 2001; 7:2344-2346. Published online August 1, 2001:5321-5325.

[8] Kanamori Y, Matsushima M, Minaguchi T, Kobayashi K, Sagae S,Kudo R, Terakawa N, Nakamura Y. Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion/deletion polymorphism in its promoter region. Cancer Res. 1999; 59:4225-4227.

[9] Zhu Y, Spitz MR, Lei L, Mills GB, Wu X. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. Cancer Res. 2001; 61:7825-7829.

[10] Vincenti MP, Coon CI, Brinckerhoff CE. Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. Arthritis Rheum .1998; 41:1987-1994 .

[11] Sylvia D, Lechtenebohmer N, Rau R , Getraud H B , Wagner U, Bertram U O, Hannsmann I, Keyzers G. Association of na specific haplotype across the genes MMP1 , and MMP3 with radiographic joint destruction in rehmoboid arthritis. J Arithritis Res ther .2004; 6:r199-r207.

[12] Fujimoto T, Parry S, Urbanek M, Sammel M, Macones G, Kuivaniemi H, Romero R, Strauss JF. A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes. J Biol Chem. 2002; 277: 6296–6302.

[13] Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature. 1999; 18; 398(6724): 252-256.

[14] Karin M, Ben-Neriah Y.Phosphorylation meets ubiquitination: the control of NFkB activity. Annu Rev Immunol. 2000;18:621-663.

[15] Bondeson J, Brennan F, Foxwell B, Feldmann M. Effective adenoviral transfer of I Kappa B alpha into human fibroblasts and chondrosarcoma cells reveals that the induction of MMP and proinflammatory cytokines is nuclear factor kappa B dependent. J Rheumatol .2000; 27:2078-2089.

[16] Xia G, Harhaj EW, Sun Sc. NFkB inducing kinase regulates the processing of NFkB2 p100. Mol cell .2001; 7:401-409.

[17] Fertsch D, Schoenberg DR, Germain RN. Induction of macrophage Ia antigen expression by rIFN-γ and down-regulation by IFN-α/β and dexamethasone are mediated by changes in steady state levels of Ia mRNA. J Immunol.1987; 139:244–249.


Repository Staff Only: item control page