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Antipyretic activity of azima tetracantha in experimental animals

Tajuddin Nargis Begum, Mohamed Hussain Muhammad Ilyas, Arumugam Vijaya Anand , Int J Cur Biomed Phar Res. (2011) Antipyretic activity of azima tetracantha in experimental animals. [Journal (Paginated)]

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Abstract

In the present study, the ethanolic leaf extract of Azima tetracantha Lam (A. tetracantha) was investigated for antipyretic activity in rats using Brewer’s yeast induced Pyrexia. The leaves of A. tetracantha were collected from Ponnamaravathi and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1 ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of A. tetracantha 100 and 200 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with A. tetracantha extract at a dose of 100, 200 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 200 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25 mg/kg and tested drug A. tetracantha extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group.

Item Type:Journal (Paginated)
Keywords:Azima tetracantha, antipyretic, Brewer’s yeast, paracetamol,
Subjects:JOURNALS
ID Code:7331
Deposited By: CurrentSciDirect Publications, International Journal of Current Biomedical and Pharmaceutical Research (IJCBPR)
Deposited On:02 May 2011 15:50
Last Modified:02 May 2011 15:50

References in Article

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1. Chattopadhyay D, Arunachalam G, Ghosh L, Rajendran AB, Bhattacharya SK. Antipyretic activity of Alstonia macrophylla Wall exA. DC: An ethnomedicine of Andaman Islands. Journal of Pharmacy and Pharmaceutical Science. 2005; 8:558-564.

2. Spacer CB, Breder CD. The neurologic basic of fever. New England Journal of Medicine. 1994; 330:1880-1886.

3. Veugelers PJ, Kaldor JM, Strathdee SA, Page-Shafer KA, Schechter MT, Coutinho RA, Keet, IP Van Grienseven GJ. Incidence and prognostic significance of symptomatic primary human immuno deficiency virus type Infection in homosexual men. Journal of Infectious Disease. 1997; 176:112-117.

4. Guyton AC, Hall JE. Textbook of Medical physiology. 9th ed. W.B. Saunders company, Philadelphia. 1998; PP:920-922.

5. Loux JJ, Depalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxical APPL Pharmacol. 1972; 22:672-675.

6. Kinsella JE, Lokesh B, Broughton S. Dietary polyunsaturated fatty acid and eicosanoids; Potential effects on the modulation of inflammatory and immuned cells: an overview. Nutrition. 1990; 6:24-44.

7. Gupta MB, Nath R, Srivastava N. Anti-inflammatory and antipyretic activities of beta sitosterol. Internat J Immunopharmacol. 1996; 18:693-700.

8. Bouic PJD. Plant sterols and sterolins: A review of their immune modulating properties. Altern Med Rev. 1999; 4:170-177.

9. Wagner H. Immunostimulants and adaptogens from plants. In: Amason, JT., Mata, R., and Romeo, JT. Phytochemistry of Medicinal Plants. Plenum Press. New York. 1995; pp.1-18.

10. Clark WO, Cumby HR. The antipyretic effect of Indomethacin. J Physiol. 1975; 248:625-638.

11. Jalapure SS, Habbu PV, Patil MB, Kulkani RV, Simpi CC, Patil CC. Analgesic and antipyretic activity of Pergularia extensa in rats. Indian Journal of Pharmaceuticol Sciences. 2002; 64(5):493-495.

12. Ramaswamy S, Pillai NP, Gopalkrishnan V, Parmar NS, Ghosh MN. Analgesic effect of O (Beta hydroxyethyl) rutoside in mice. Indian J. Exp. Biol. 1985; 23:219-220.

13. Hajare SW, Suresh Chandra SK, Tandan J, Sarma J, Lal AG. Analgesic and antipyretic activities of Dalbergia sissoo leaves. Indian Journal of Pharmacology. 2000; 32:357-360.

14. Ray D, Sharatchandra KH, Thokchom IS. Antipyretic, antidiarrhoeal, hypoglycaemic and hepatoprotective activities of ethyl acetate extract of Acacia catechu willd in albino rats. Indian J Pharmacol. 2006; 38(6):408-413.

15. Mathew AG, Parpia HAB. Food browning as a polyphenol reaction. In: Chichester CO, Mark EM, Stewart GF, editors. Advances in food research New York: Academic Press. 1971; pp. 75-145.

16. Rajnarayana K, Reddy MS, Chaluvadi MR, Krishna DR. Bioflavonoids classification,pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol. 2001; 33:2-16.

17. Amiruddin Z, Gopalan HK, Zainal H, Mohd Pojan NH, Morsid NA, Aris A, Sulaiman MR. Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum choloroform extract in animal models. The Pharmaceutical society of Japan. 2006; 126(11):1171-1178.

18. Njunge K, Muriuki G, Mwangi JW, Kuria KA. Analgesic and antipyretic effects of Myrica salicifolia (Myricaceae). Phytother Res Mar. 2002; 16 suppl 1:S73-74.

19. Alam K, Abdullahil Baki M, Abdul Alim A, Sohel Hasan M, Rahman M, Ekramul Haque M. Antipyretic activity of roots of Laportea crenulata Gaud in rabbit. Research Journal of Medicine and Medical Sciences. 2007; 2(2):58-61.

20. Chattopadhyay D, Arunachalam G, Ghosh L, Rajendran AB, Bhattacharya SK. Antipyretic activity of Alstonia macrophylla Wall exA. DC: An ethnomedicine of Andaman Islands. Journal of Pharmacy and Pharmaceutical Science. 2005; 8:558-564.

21. Brasseur T. Anti-inflammatory properties of flavonoids. Journal de pharmacie de Belgique. 1989; 44:235-241.

22. Vimala R, Nagarajan S, Alam M, Susan T, Joy S. Anti-inflammatory and antipyretic activity of Michelia champaca Linn. (White variety). Ixora brachiata Roxb and Rhynchosia cana (wild.) D.C. flower extract. Indian J Exp Biol. 1997; 35:1310-1314.

23. Yongna Z, Wantana R, Pisit B, Zhongkun L, Rongping Z. Analgesic and antipyretic activities of aqueous extract of Urtica macrorrhiza in experimental animals. Fitoterapia. 2005; 76:91-95.

24. Mutalik S, Paridhavi K, Mallikarjuna Rao C, Udupa N. Antipyretic and analgesic effect of Solanum melongena. Indian Journal of Pharmacology. 2003; 35:312-315.

25. Chueh FS, Chang CP, Chio CC, Lin MT. Puerarin acts through brain serotoninergic mechanism to induce thermal effects. Journal of Pharmacological Sciences. 2004; 96(4):420-427.

26. Kerr K, Mabry T, Joser S. 6-hydroxy and 6 methoxy flavonoids from Neurolaena lobata and Neurolaena macrocephala. Phytochemistry. 1981; 20(4):791-794.

27. Yasuda T, Endo M, Kon-on T, Kato T, Mitsuzuka M, Ohsawa K. Antipyretic, analgesic and muscle relaxant activities of pueraria isoflavonoids and their metabolites from Pueraria lobata Ohwi- a traditional Chinese drug. Biological and Pharmaceutical Bulletin. 2005; 28(7):1224-1228.

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