Dopaminergic Regulation of Neuronal Circuits in Prefrontal Cortex

Scheler, Gabriele (2001) Dopaminergic Regulation of Neuronal Circuits in Prefrontal Cortex. [Journal (On-line/Unpaginated)] (In Press)

Full text available as:

PDF (Journal Article accepted at Neural Networks 2001, never published) - Accepted Version


Neuromodulators, like dopamine, have considerable influence on the processing capabilities of neural networks. This has for instance been shown in the working memory functions of prefrontal cortex, which may be regulated by altering the dopamine level. Experimental work provides evidence on the biochemical and electrophysiological actions of dopamine receptors, but there are few theories concerning their significance for computational properties (ServanPrintzCohen90,Hasselmo94). We point to experimental data on neuromodulatory regulation of temporal properties of excitatory neurons and depolarization of inhibitory neurons, and suggest computational models employing these effects. Changes in membrane potential may be modelled by the firing threshold, and temporal properties by a parameterization of neuronal responsiveness according to the preceding spike interval. We apply these concepts to two examples using spiking neural networks. In the first case, there is a change in the input synchronization of neuronal groups, which leads to changes in the formation of synchronized neuronal ensembles. In the second case, the threshold of interneurons influences lateral inhibition, and the switch from a winner-take-all network to a parallel feedforward mode of processing. Both concepts are interesting for the modeling of cognitive functions and may have explanatory power for behavioral changes associated with dopamine regulation.

Item Type:Journal (On-line/Unpaginated)
Additional Information:Paper was not published in 2001; certain theoretical aspects of dopamine modulation outlined in the paper, esp. on ensemble formation, remain unexplored and potentially significant.
Keywords:synchronization, spiking neural networks, neuromodulation, dopamine, cortical networks, spike frequency adaptation, ensemble formation
Subjects:Psychology > Cognitive Psychology
Neuroscience > Computational Neuroscience
Computer Science > Neural Nets
Neuroscience > Neural Modelling
Neuroscience > Neuropsychology
Neuroscience > Neuropsychiatry
ID Code:8082
Deposited By: Scheler, Dr Gabriele
Deposited On:09 Nov 2012 19:34
Last Modified:09 Nov 2012 19:34

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

J.H. Callicott, V.S. Mattay, A.~Bertolino, K.~Finn, R.~Coppola, J.A. Frank, T.E. Goldberg, and D.R. Weinberger. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cerebral Cortex, 9(1):20--26, 1999.

J.~D. Cohen and D.~Servan-Schreiber. A theory of dopamine function and its role in cognitive deficits in schizophrenia. Schizophrenia Bulletin, 19(1):85--104, 1993.

J.~Cohen and M.~Usher. A neural network model of Stroop interference and facilitation effects in schizophrenia. Biological Psychiatry, 9:237, 1996.

J.~Cohen, E.Targ, D.~Servan-Schreiber, and D.~Spiegel. The fabric of thought disorder: A cognitive neuroscience approach to disturbances in the processing of context in schizophrenia. In: Cognitive Science and clinical disorders. San Diego, CA:Academic Press, 1992.

S.M. Crook, G.B. Ermentrout, and J.M. Bower. Spike frequency adaptation affects the synchronization properties of networks of cortical oscillations. Neural Computation, 10(4):837--854, 1998.

R.C. deCharms and M.M. Merzenich. Primary cortical representations of sounds by the coordination of action-potential timing. Nature, 381(6583):610--613, 1996.

S.~Dehaene, M.~Kerszberg, and J.P. Changeux. A neuronal model of a global workspace in effortful cognitive tasks. Proceedings of the National Academy of Sciences, USA, 95(24):14529--14534, 1998.

Robert Desimone. Is dopamine a missing link? Nature, 376:549--550, 1995.

Jean-Marc Fellous and Christiane Linster. Computational models of neuromodulation. Neural Computation, 10(4), May 1998.

E.E. Fetz. Temporal coding in neural populations? Science, 278(5345):1901, December 1997.

P.~Fries, PR~Roelfsema, AK~Engel, P~Konig, and W.~Singer. Synchronization of oscillatory response in visual cortex correlates with perception in interocular rivalry. Proceedings of the National Academy of Sciences, 94(23):12699--12704, 1997.

Wulfram Gerstner. Spiking neurons. In W.~Gerstner and C.~Bishop, editors, Pulsed Neural Networks. MIT Press, 1998.

A.~Gobert, J.-M. Rivet, V.~Audinot, A.~Newman-Tancredi, L.~Cistarelli, and M.J.Millan. Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release. Neuroscience, 84(2):413--429, 1998.

P.S. Goldman-Rakic, E.C. Muly, and G.V. Williams. D1 receptors in prefrontal cells and circuits. Brain Research Reviews, 31:295--301, 2000.

P.S. Goldman-Rakic. Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In Handbook of Physiology: The Nervous System, volume~5, pages 373--417. 1987.

A.~Grobin and A.Y. Deutch. Dopaminergic regulation of extracellular {GABA} levels in the prefrontal cortex of the rat. Journal of Pharmacology and Experimental Therapeutics, 285(1):350--357, 1998.

H.C. Grunze, D.G. Rainnie, M.E. Hasselmo, E.~Barkai, E.F. Hearn, R.F. McCarley, and R.W. Greene. NMDA-dependent modulation of CA1 local circuit inhibition. Journal of Neuroscience, 16(6):2034--2043, 1996.

D.~Hansel and H.~Sompolinsky. Modeling feature selectivity in local cortical circuits. In C.~Koch and I.~Segev, editors, Methods in Neuronal Modeling: From Ions to Networks, pages 499--568. MIT Press, 1998.

M.~Hasselmo. Runaway synaptic modification in models of cortex: Implications for Alzheimer's disease. Neural Networks, 7:13--40, 1994.

Michael Hasselmo. Neuromodulation and cortical function. Behavioral and Brain Research, 67(1-27), 1994.

E.J. Hess, A.B. Norman, and I.~Creese. Chronic treatment with dopamine receptor antagonists: behavioral and pharmacological effects on D1 and D2 dopamine receptors. Journal of Neuroscience, 8(7):2361--2370, 1988.

O.~Jensen and J.E. Lisman. Novel lists of 7 +/- 2 known items can be reliably stored in an oscillatory short-term memory network: interaction with long-term memory. Learning and Memory, 3(2-3):257--263, 1996.

S.~Kitai, P.D. Shepard, J.C. Callaway, and R.~Scroogs. Afferent modulation of dopamine neuron firing patterns. Current Opinion in Neurobiology, 9:690--697, 1999.

D.S. Levine. Introduction to Neural and Cognitive Modeling. Lawrence Erlbaum, 1991.

S.~J. Luck and E.K. Vogel. The capacity of visual working memory for features and conjunctions. Nature, 390:279--281, 1997.

Jacques Ludik and Dan~J. Stein. Neural modelling of cognitive disinhibition and neurotransmitter dysfunction in OCD.Proceedings of ICANN, Lecture Notes in Artificial Intelligence. Springer, 1996.

Wolfgang Maass. Networks of spiking neurons: The third generation of neural network models. Neural Networks, 10(9):1659 -- 1673, 1997.

M.A. Mehta, A.M. Owen, B.J. Sahakian, N.~Mavaddat, J.D. Pickard, and T.W. Robbins. Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. Journal of Neuroscience, 20(RC65):1--6, 2000.

R.~Miller. Hyperactivity of associations in psychosis. Aust N Z Joural of Psychiatry, 23(2):241--248, June 1989.

P.G. Nestor and B.F. O'Donnell. The mind adrift: Attentional dysregulation in schizophrenia. In R.~Parasuraman, editor, The Attentive Brain, pages 527--546, MIT Press, 1998.

P.~Pedarzani and J.F. Storm. Dopamine modulates the slow Ca2+-activity K+ current IAHP via cyclic AMP-dependent protein kinase in hippocampal neurons. Journal of Neurophysiology, 74(6):2749--2753, 1995.

S.~Retaux, MJ~Besson, and J.~Penit-Soria. Opposing effects of dopamine {D2} receptor stimulation on the spontaneous and the electrically evoked release of [3H] GABA on rat prefrontal cortex slices. Neuroscience, 42(1):61--71, 1991.

T.~Sawaguchi and P.~S. Goldman-Rakic. D1 dopamine receptors in prefrontal cortex: Involvement in working memory. Science, 251:947--950, 1991.

G.~Scheler and J.-M. Fellous. A neural model of lexical selection and its modulation by dopamine. Proceedings of the International Joint Conference on Neural Networks, Como, Italy, July 2000.

G.~Scheler. A theoretical view on dopamine regulation. In G.~M. Georgiu, editor, Proceedings of the third International Conference on Computational Intelligence and Neuroscience, 1998.

G.~Scheler. Regulation of neuronal firing in VTA. (preprint), 2000.

J.K. Seamans, T.J. Sejnowski, and C.~Stevens. Dopamine {D1} receptor activation enhances sustained synaptic inputs to prefrontal cortex neurons. Journal of Neuroscience (submitted), 2000.

D.~Servan-Schreiber, W.~Printz, and J.D. Cohen. A network model of catecholamine effects. Science, 249:892--895, 1990.

D~Servan-Schreiber, J~Cohen, and S~Steingard. Schizophrenic deficits in the processing of context: A test of a theoretical model. Archives of General Psychiatry, 53(12):1105--1112, 1996.

M.N. Shadlen and W.T. Newsome. Noise, neural codes and cortical organization. Current Opinion in Neurobiology, 4:569, 1994.

W.~Singer and C.M. Gray. Visual feature integration and the temporal correlation hypothesis. Annual review of neuroscience, 18:349--374, 1995.

K.~Starke. Grundlagen der Pharmakologie des Nervensystems. Pharmakologie und Toxikologie, pages 103--133. Springer, 1997.

David~C. Tam. A cross-interval spike train analysis: the correlation between spike generation and temporal integration of doublets. Biological Cybernetics, 78(2):95--106, 1998.

M.~Usher and N.~Donnelly. Visual synchrony affect binding and segmentation in perception. Nature, 394:179--182, 1998.

M.~Usher, J.~D. Cohen, D.~Servan-Schreiber, J.~Rajkowski, and G.~Aston-Jones. The role of locus coeruleus in the regulation of cognitive performance. Science, 283(5401):549--554, 1999.

C.~von der Malsburg. The correlation theory of brain function. In K.~Schulten and L~van Hemmen, editors, Models of Neural Networks 2. Springer, 1994.

C.~von der Malsburg. Binding in models of perception and brain function. Current Opinion in Neurobiology, pages 520-- 526, 1995.

L.~Wiskott and C.~v.d. Malsburg. Face recognition by dynamic link matching. In J.~Sirosh, R.~Miikkulainen, and Y.Choe, editors, Lateral Interactions in the Cortex: Structure and Function. 1995.

CR~Yang and JK~Seamans. Dopamine {D1} receptor actions in layers {V-VI} rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration. Journal of Neuroscience, 16(5):1922--1935, 1996.

J.~Zahrt, J.R. Taylor, R.G.Mathew, and A.Arnsten. Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance. Journal of Neuroscience, 17(21):8528--8535, 1997.


Repository Staff Only: item control page