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The Association of Antidepressant Medication and Body Weight Gain

Ranjbar, Sara and Pai, Nagesh Brahmavar and Deng, Chao (2013) The Association of Antidepressant Medication and Body Weight Gain. [Journal (On-line/Unpaginated)]

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Abstract

Objective: To review the literature and discover which antidepressants are responsible for weight gain and then to discuss the areas with lack of adequate knowledge. Method: An electronic search was conducted through Medline, Pubmed, Cochrane library, and ScienceDirect. Forty nine empirical researches were identified and reviewed. Results: Amitriptyline, clomipramine, and mirtazapine have been associated with more weight gain induction in clinical studies, but not in animal-based studies. All TCAs have been reported to cause weight gain except protriptyline. MAOIs have been associated with weight gain. In SSRI group, citalopram and ecitalopram induce weight, yet mixed results exist for paroxetine and fluoxetine. Researches unanimously reported weight loss effect for bupropion. Some studies suggest contributing factors in the relationship of antidepressants with body weight changes including age, gender, base-line weights and treatment duration. Various results of different treatment durations have been reported in some cases but there are not continuous time-dependent studies for the influences of antidepressants on body weight changes. Conclusion: More studies are required to discover underlying mechanisms and the time-dependent effects of antidepressants on body weight changes.

Item Type:Journal (On-line/Unpaginated)
Keywords:Antidepressants; Body weight; Obesity
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
Neuroscience > Neuropharmacology
ID Code:9135
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:25 Feb 2014 12:40
Last Modified:25 Feb 2014 12:40

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