Chromophobe Renal Cell Carcinoma

Wader, JV and Kumbhar, SS and Huddedar, AD and Khatib, WGM (2013) Chromophobe Renal Cell Carcinoma. [Journal (On-line/Unpaginated)]

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Renal cell carcinoma is the most common neoplasm of the kidney comprised of different histological variants. Chromophobe renal cell carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC) mainly diagnosed in the sixth decade of life. It is important to identify this entity because it has significantly better prognosis than the clear cell (conventional) and papillary renal cell carcinomas. The chromophobe renal cell carcinoma should be differentiated from oncocytoma and clear cell carcinoma. We report a case of a 70 year-old male who presented with a six month history of hematuria, left sided flank pain and a palpable non-tender lump in the left lumbar region. On radiology, the possibility of a left renal neoplasm was raised. A left radical nephrectomy was done and histopathological diagnosis of Type 2 (mixed) chromophobe renal cell carcinoma was given. We present this case owing to its relative rarity of incidence, difficulties encountered and differential diagnoses to be considered during diagnosis as the prognosis and management protocols differ with different variants.

Item Type:Journal (On-line/Unpaginated)
Keywords:Chromophobe renal cell carcinoma; Type 2 mixed variant
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:9148
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:25 Feb 2014 12:41
Last Modified:25 Feb 2014 12:41

References in Article

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1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010:15;2893-2917.

2. Ljungberg B et al. The Epidemiology of Renal Cell Carcinoma. Eur Urol. Oct 2011;60(4):29-36.

3. Ordonez NG, Rosai J. Urinary Tract: Kidney, Renal pelvis and Ureter; Bladder. In: Rosai and Ackerman’s Surgical Pathology. 10th ed. Vol(2). Mosby Elsevier. 2011. pp 1183-1193.

4. Crotty TB, Farrow GM, Lieber MM. Chromophobe cell renal carcinoma: Clinicopathological features of 50 cases. J Urol. 1995;154:964-967.

5. Eble JN, Sauter G, Epstein JI, Sesterhenn IA. Pathology and Genetics of the tumors of the urinary system and male genital organs. WHO classification of Tumours. IARC Press; Lyon, France. 2004.

6. Thoenes W, Storkel S, Rumpelt MJ. Human chromophobe cell renal carcinoma. Virchows Arch Cell Pathol. 1985;48:207–217.

7. Stec R, Grala B, Maczewski M, Bodnar L, Szczylik C. Chromophobe renal cell cancer - review of the literature and potential methods of treating metastatic disease. J Exp Clin Cancer Res. 2009;28(1):134.

8. Alpers CE. The Kidney. In: Kumar V, Abbas A, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic basis of disease. 8th ed. Saunders Elsevier. 2010. pp 963-967.

9. Cheville JC, Lohse CM, Zincke H, Weaver H, Blute AL, Michael L. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol. 2003;27:612-624.

10. Vera-Badillo FE, Conde E, Duran I. Chromophobe renal cell carcinoma: A review of an uncommon entity. Int J Urol. May 2012:1-7.

11. Akhthar M, Kardar H, Linjawi T, McClintock J, Ali MA. Chromophobe cell carcinoma of the kidney: A clinicopathologic study of 21 cases. Am J Surg Pathol 1995;19:1245–1256.

12. Onishi T, Oishi Y, Yauda S, Abe K, Hasegawa T, Maeda S. Prognostic implications of histological features in patients with chromophobe RCC. BJU Int. 2002;90:529–532.


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