Red Cell Genetic Markers in Malarial Susceptibility and Selective Advantage Hypothesis

Balgir, RS (2014) Red Cell Genetic Markers in Malarial Susceptibility and Selective Advantage Hypothesis. [Journal (On-line/Unpaginated)]

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Malaria is still a serious public health challenge in many parts of the world including India. Human genetic susceptibility to malaria varies from individual to individual depending upon the genetic constitution and from region to region based on geo-ecological and climatic conditions. In the present study, intravenous 334 random blood samples of unrelated adult individuals belonging to Mongoloid ethnic stock were taken after informed consent from the endemic localities of Arunachal Pradesh, Assam and Nagaland to find out the relationship between the abnormal hemoglobin and G6PD enzyme deficiency, and susceptibility to malaria. Abnormal hemoglobin E and G6PD enzyme deficiency seem to interact with malarial parasite in such a way that they probably provide decreased susceptibility or inhibitory effect or increased resistance. Genetic alterations in human genome are maintained in the specific population by natural selection to protect the host against the malarial infection. These findings are consistent with those studies which support the notion of selective genetic advantage hypothesis against the malaria infection.

Item Type:Journal (On-line/Unpaginated)
Keywords:Red cell genetic markers; Hemoglobin E; G6PD deficiency; Malaria susceptibility; Natural selection; North-Eastern India.
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:9712
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:21 Feb 2015 14:35
Last Modified:20 Apr 2015 11:43

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Nora JJ, Fraser FC. Medical Genetics: Principles and Practice. Philadelphia: Lea and Febiger. 1981. pp 274.

2. Balgir RS. Serogenetic Variations in a Mech-Kachari Tribal Population. Man in India. 1992;72:293-301.

3. Balgir RS. Genetic markers in the tribal health, development and welfare with special reference to North-Eastern India. In: Anthropology, Population and Development. JC Sharma (Ed). New Delhi: Inter-India Publications.1995. pp 151-171.

4. Balgir RS. Emerging trends in genetic epidemiology of hemoglobinopathy in the seven sister states of North-Eastern India. In: North East India in Perspectives: Biology, Social Formation and Contemporary Problems. Das RajatKanti&BasuDebashish (Eds.). New Delhi: Akansha Publishing House. 2005. pp 17-37.

5. Jaggi OP. All About Malaria: Causes, Prevention and Cure. New Delhi: Orient Paperbacks. 1978. pp 33-35.

6. WHO Technical Report. Standardization of Procedures for the Study of Glucose-6- Phosphate Dehydrogenase. WHO Tech Rep Ser No. 366. 1967. pp 35-45.

7. Dacie JV, Lewis SM. Practical Hematology. 7th Edn. Edinburgh: Churchill Livingstone. 2001. pp 227–257.

8. Weatherall DJ. The Thalassemias. In: Methods in Hematology. Vol. 6. New York: Churchill Livingstone. 1983. pp 1-53.

9. Balgir RS. Ethnic and regional variations in the erythrocytic glucose-6-phosphate dehydrogenase deficiency in India. Indian Practr 1995;48:127-135.

10. Balgir RS. Do tribal communities show inverse relationship between sickle cell disorders and glucose-6-phosphate dehydrogenase deficiency in malaria endemic areas of Central-Eastern India? Homo – J Compar Hum Biol2006;57:163-176.

11. Balgir RS. High occurrence of G-6-PD deficiency and diversity of hemoglobin variants in Bhuyan primitive tribe of Sundargarh district in Northwestern Orissa, India. Int Public Health J 2011;3:281-288.

12. Balgir RS. Community expansion and gene geography of sickle cell trait and G6PD deficiency and Natural Selection against malaria: Experience from tribal land of India. CardiovasculHemat Agents Med Chemistry. 2012;10:3-13.

13. Balgir RS, Mishra Shakti Prava. Do abnormal hemoglobin and allied disorders confer protection to inhabitants against malaria endemic geo-ecological environment? Tribal Health Bulletin 2013;19(1 & 2):30-40.

14. Yuthavong Y, Butthep P, Bunyartvej A, Fucharoen S. Inhibitory effect of ß-thalassemia/hemoglobin E erythrocytes on Plasmodium falciparum growth in vitro. Trans Royal Soc Trop Med Hyg 1987;80:903-906.

15. Ghosh TN. Factors of human genetics in malaria. In: Proceedings of Indo-UK Workshop on Malaria. Delhi: Malaria Research Centre (ICMR). 1983. pp 251-267.

16. Weatherall DJ, Clegg JB. The Thalassemia Syndromes. 3rdedn. Oxford: Blackwell Scientific Publications. 1981. pp 312-317.

17. Luzzatto L, Usanga EA, Reddi S. Glucose 6 phosphate dehydrogenase deficient cells: resistance to infection by malarial parasites. Science 1969;164:839-842.

18. Vasantha K, Gorakhshaker AC, Pavri RS, Bhatia HM. Genetic markers in malaria endemic tribal populations of Dadra and Nadar Haveli. In: Proceedings of Recent Trends in Hematology. Bombay: Institute of Immunohematology (ICMR).1982. pp 162-168.

19. Joshi H, Raghavendra K, Subbarao SK, Sharma VP. Genetic markers in malaria patients of Delhi. Indian J Malar 1987;24:33-38.


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