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Rugg, MD, Pearl, S, Walker, P, Roberts, RC, Holdstock, JS (). WORD
REPETITION EFFECTS ON EVENT-RELATED POTENTIALS IN HEALTHY-YOUNG AND OLD
SUBJECTS, AND IN PATIENTS WITH ALZHEIMER-TYPE DEMENTIA.
Keywords: RECOGNITION MEMORY, BRAIN POTENTIALS, FREQUENCY WORDS, P300,
DISSOCIATION, PERFORMANCE, MODULATION, DISEASE, TASK
Other papers which cite
this article
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Abstract
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Event-related potentials (ERPs) were recorded from 16 healthy young (mean
age 21 years) and 16 healthy old subjects (mean age 64 years), and from
11 subjects with a diagnosis of Dementia of Alzheimer Type (DAT). The task
requirement was to attend to a series of visually presented words so as
to respond to occasional animal names. Non-animal names repeated after
either a single or six intervening items. In the young subjects ERPs evoked
by repeated words displayed a widespread, sustained positive-going shift
relative to ERPs evoked by first presentations (the ERP repetition effect).
This effect onset around 220 msec and did not differ as a function of inter-item
lag. Other than for a delay in onset of approximately 80 msec, the ERP
repetition effect in the healthy old group was in all respects equivalent
to that of the young subjects. The ERP repetition effects in the DAT patients
were statistically indistinguishable from those of an appropriately matched
sub-set of the healthy old subjects.
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