ECS Intranet:
Submicron fabrication of biomolecular patterns using optical methods

We have developed a new method for writing of biomolecular patterns on silicon in sub-micron scales using the interference of light. In the first instance DNA patterned surfaces were fabricated. Covalent attachment of DNA oligonucleotides accessible towards hybridisation with a complementary sequence was achieved with very high density (one oligonucleotide per 16 nm²). Further development of the surface attachment chemistry has provided DNA modified patterned substrates for hybridisation with long DNA fragments.

Homepage: http://www.orc.soton.ac.uk/290.html
Type: Normal Research Project
Research Group: Optoelectronics Research Centre
Themes: Medical Engineering, Nanoelectronics
Dates: 1st October 2002 to 31st December 2008

Keywords

• biophotonics
• biosensor
• DNA analysis
• lab-on-a-chip
• nanobiotechnology

Funding

• BBSRC

Principal Investigators

• Dr Tracy Melvin

Other Investigators

• Tom Brown, School of Chemistry
• Human Genetics, School of Medicine

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