ECS Intranet:
Parallel Electrophysiological Characterization of Sodium Channels
This proposal aims to exploit a novel platform for parallel on-chip electrophysiology, developed at the University of Southampton, for the functional characterization of a family of voltage-gated sodium channels, including human/bacterial chimeras, for which the expression, purification and reconstitution into liposomes is being developed at Birkbeck College. Specifically, the project will use this high-throughput platform to identify novel ligands/drugs that modulate the conductance properties of the sodium channels.
Type: Normal Research Project
Research Groups: Nano Research Group, Southampton Nanofabrication Centre
Themes: Healthcare in ECS, Microfluidics and Lab-on-a-chip, Bionanotechnology and Biosensors
Dates: 1st October 2010 to 30th September 2014
Partners
- Birkbeck College, London
- University of Bologna
Funding
- EPSRC
Principal Investigators
- Professor Hywel Morgan
- Dr Maurits RR De Planque
- Prof. Bonnie Wallace (Birkbeck)
- Prof. Marco Tartagni (Bologna)
Other Investigators
- Mr Sumit Kalsi
- Dr Shimul Saha
- Mr Alex Henderson (Birkbeck)
- Dr Andy Powl (Birkbeck)
You can edit the record for this project by visiting http://secure.ecs.soton.ac.uk/db/projects/editproj.php?project=738
