The calculation of CKM matrix elements allows us to constrain the parameter space available to new physics. Experimental data for leptonic decay rates can be related to CKM matrix elements via kinematic factors known analytically and decay constants calculated using on lattice QCD. The precision of lattice determination of decay constants has reached percent level precision and in order to improve upon this isospin-breaking corrections, that are usually small enough to be safely neglected, must be included. In this talk we will discuss the calculation of these corrections on the lattice and how new methods can be employed to achieve the improvement in precision required.