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Effect Of Oestradiol On Mouse Vaginal Epithelium

Shetty, Dr. Prakash and Prabhu V, Dr. Latha and Pai M, Dr. Mangala (2006) Effect Of Oestradiol On Mouse Vaginal Epithelium. [Journal (On-line/Unpaginated)]

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Abstract

Oestradiol which induces the proliferation of the vaginal epithelium is used in the oestrogen replacement therapy for menopausal and postmenopausal disorders. The exact onset of induced cell proliferation and recovery to the controlled level has not been reported before. Hence this study was done in ovariectomised mice and the period of cellular response to ethinyl estradiol, a semisynthetic ester (0.025mg/kg) was recorded. The vaginal epithelium was studied for histological changes and incidence of mitotic figures. The onset of proliferation started at 4h after exposure and reached its maximum at 32h and declined gradually thereafter to reach the base level at 60h.

Item Type:Journal (On-line/Unpaginated)
Keywords:Oestradiol, Mitotic figures, Vaginal epithelium
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:4848
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:21 Apr 2006
Last Modified:11 Mar 2011 08:56

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Parfit K. Martindale: The complete drug reference, 32nd ed. Pharmaceutical press, Massachusetts, 1999.

2. Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993; 341:1392-1395.

3. Henderson BE. The cancer question: an overview of recent epidemiologic and retrospective data. Am J Obstet Gynecol 1989; 161: 1859-1864.

4. Dupont WD, Page DL. Menopausal oestrogen replacement therapy and breast cancer. Arch Intern Med 1991; 151: 67-72.

5. Hisano N. effects on hamster vaginal development of single dose of testosterone on oestradiol given neonatally. Acta Anat (Basel) 1997; 97(4): 361-370.

6. Solomon J, Cocchia MA, DiMartino R. Effect of delta-tetrahydrocannabinol on uterine and vaginal cytology of ovariectomised rats. Science 1977; 195(5281): 875-877.

7. Ivasenko IN. Effect of simultaneous administration of oestradiol and progesterone on proliferative pool of the uterine and vaginal epithelium in castrated rats. Arkh Anat Gistol Embriol 1978; 74(40: 79-84.

8. Wong LM, Bern HA, Jones LA, Mills KT. Effect of later treatment with estrogen on reproductive tract lesions in neonatally estrogenised female mice. Cancer Lett 1982; 17(2): 115-123.

9. Sanyal AK, Singh S, Singh SP. Response of vaginal epithelium and quantitative estimation of its cellular proliferation in overiectomised rats after a single administration of oestradiol. Acta Anat 1974; 87: 82-92.

10. Edelman DA. Diethylstillbesterol exposure and the risk of clear cell cervical and vaginal adenocarcinoma. Int J Fertil 1989; 34 (4): 251-255.

11. Forsberg JG. Treatment with different antiestrogens in the neonatal period and effects in the cervicovaginal epithelium and ovaries of adult mice: a comparison to oestrogen-induced changes. Biol Reprod 1985; 32(2): 427-441.

12. Markey CM, Wadia PR, Rubin BS, Sonnenschein C, Soto AM. Long term effects of fotal exposure to low doses of the xenoesterogen bisphenol-A in the female mouse genital tract. Biol Reprod 2005; 72(6): 1344-1351.

13. Masui F, Matsuda M, Mori T. Vitamin A prevents the irreversible proliferation of vaginal epithelium induced by neonatal injection of keratinocyte growth factor in mice. Cell Tissue Res. 2003; 311(2): 251-258.

14. Tansey G, Hughs CL Jr, Cline JM, Krummer A, Walmer DK, Schmoltzer S. Effects of dietary soybean estrogens on the reproductive tract in female rats. Proc oc Exp Biol Med 1998; 217(3): 340-344.

15. Kimura T, Kawashima S, Nishizuka Y. effects of prenatal treatment with estrogen on mitotic activity of vaginal anlage cells in mice. Endocrinol Jpn 1980; 27(6): 739-745

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