Solitonic Effects of the Local Electromagnetic Field on Neuronal Microtubules

Georgiev, Danko and Papaioanou, Stelios and Glazebrook, James (2007) Solitonic Effects of the Local Electromagnetic Field on Neuronal Microtubules. [Journal (Paginated)]

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Current wisdom in classical neuroscience suggests that the only direct action of the electric field in neurons is upon voltage-gated ion channels which open and close their gates during the passage of ions. The intraneuronal biochemical activities are thought to be modulated indirectly either by entering into the cytoplasm ions that act as second messengers, or via linkage to the ion channels enzymes. In this paper we present a novel possibility for subneuronal processing of information by cytoskeletal microtubule tubulin tails and we show that the local electromagnetic field supports information that could be converted into specific protein tubulin tail conformational states. Long-range collective coherent behavior of the tubulin tails could be modelled in the form of solitary waves such as sine-Gordon kinks, antikinks or breathers that propagate along the microtubule outer surface, and the tubulin tail soliton collisions could serve as elementary computational gates that control cytoskeletal processes. The biological importance of the presented model is due to the unique biological enzymatic energase action of the tubulin tails, which is experimentally verified for controlling the sites of microtubule-associated protein attachment and the kinesin transport of post-Golgi vesicles.

Item Type:Journal (Paginated)
Keywords:soliton, electromagnetic field, neuron
Subjects:Neuroscience > Biophysics
Neuroscience > Neurophysiology
ID Code:5814
Deposited By: Georgiev, Danko
Deposited On:13 Nov 2007 00:59
Last Modified:11 Mar 2011 08:57


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