Autism’s direct cause? Failure of infant-mother eye contact in a complex adaptive system

McDowell, Doctor Maxson J (2011) Autism’s direct cause? Failure of infant-mother eye contact in a complex adaptive system. [Journal (Paginated)]

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This paper shows that an experimental hypothesis is plausible and merits testing. In brief the hypothesis is that autism begins with a failure in early learning and that changing the environment of early learning would dramatically change its incidence. Strong statistical evidence supporting this hypothesis was published by Waldman et al. (2008) but this evidence has largely been ignored, perhaps because it challenges prevalent beliefs about autism. This paper also suggests that the current epidemic of autism is serious enough, and intellectually mysterious enough, to merit attention from a wider community of cognitive scientists: new ideas are needed. A confirmation of this paper’s hypothesis would have interesting implications for cognitive science.

Item Type:Journal (Paginated)
Keywords:Autism spectrum disorder Complexity Complex dynamic system Eye contact Face recognition Infant-mother dyad Intersubjectivity Oxytocin Self-organized Television Smart phones
Subjects:Biology > Theoretical Biology
Psychology > Developmental Psychology
Neuroscience > Neuropsychology
ID Code:9124
Deposited By: McDowell, Doctor Maxson J.
Deposited On:18 Nov 2013 21:00
Last Modified:18 Nov 2013 21:00

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Abrahams, B. S. & Geschwind, D. H. (2008) Advances in autism genetics: on the threshold of a new neurobiology. Nature Reviews Genetics 9, 341-355.

Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2007). The Molecular Biology of the Cell, Fifth Edition. New York: Garland Science.

Als, H., Tronic, E. & Brazelton, T. B. (1980). Stages of early behavioral organization: the study of a sighted infant and a blind infant in interaction with their mothers. In: High-Risk Infants and Children, ed. T. M. Field, , 181-204. New York: Academic Press.

American Academy of Pediatrics Committee on Public Education (2001). Policy Statement: Children, Adolescents, and Television. Pediatrics, 107: 423-6.;107/2/423

Andari, E., Duhamel, JR., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010). Promoting social behavior with oxytocin in high- functioning autism spectrum disorders. Proceedings of the National Academy of Sciences, USA Online, February 16th.

Anderson, D. R. & Pempek, (2005). T. A., Television and very young children. American Behavioral Scientist, 48: 505-22.

Arthur, W. B. (1999). Complexity and the Economy. Science 2, 284 (5411): 107-9.

Asperger H. (1944). Die ‘autischen Psychopathen’ im Kindesalter. Archiv fur Psychiatrie und Nervenkrankheiten, 17: 76-136.

Auyeung, B., Taylor, K., Hackett, G. & Baron-Cohen, S. (2010). Foetal testosterone and autistic traits in 18 to 24-month-old children. Molecular Autism. 1(11).

Baron-Cohen S (1994). How to build a baby that can read minds: cognitive mechanisms in mindreading. Cahiers de Psychologie Cognitive, 13: 513-52.

Baron-Cohen, S. (2003). The Essential Difference: Men, Women and the Extreme Male Brain. Penguin, London.

Baron-Cohen, S., Knickmeyer, R. C., & Belmonte, M. K. (2005). Sex differences in the brain: implications for explaining autism. Science. Nov 4., 310(5749): 819-23.

Baron-Cohen, S., Wheelwright, S. & Jolliffe, T. (1997). Is there a “language of the eyes”? Evidence from normal adults and adults with autism or Asperger syndrome. Visual Cognition, 4(3): 311-31.

Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001): The Autism Spectrum Quotient (AQ): evidence from Asperger syndrome/high functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31:5-17.

Beebe, B. (2005). Mother-infant research informs mother-infant treatment. Psychoanalytic Study of the Child, 60: 7-46.

Beebe, B., Lachman, F. M. & Jaffe, J. (1997). Mother-infant interaction structures and presymbolic self- and object representations. Psychoanalytic Dialogues, 7(2): 133-82.

Bergman, A. (1985). From psychological birth to motherhood: the treatment of an autistic child with follow-up into her adult life as a mother. In: Parental influences in health and disease, eds E. J. Anthony and G. H. Pollock, 91-120. Boston: Little, Brown.

Bion, W. R. (1962/1977). Learning from experience . In: Seven Servants. New York: Jason Aronson.

Bonabeau, E., Theraulaz, G., Deneubourg, S. A., & Camzine, S. (1997). Self-organization in social insects. Trends in ecology and evolution, 12 (5): 188-93.

Bower, B. (2009). Joint attention provides clues to autism and cooperation: Different paths to childhood autism. Science News, 176(10): 15.


Broad Institute of MIT and Harvard (2008). Human gene count tumbles again. ScienceDaily.

Brown, R., Hobson, R. P., Lee, A & Stevenson, J. (1997). Are there “autistic like” features in congenitally blind children? Journal of Child Psychology and Psychiatry, 38(6): 693-703.

Byrd, R. (2002). Report to the legislature on the principle findings from “The epidemiology of autism in California: a comprehensive pilot study.” California Department of Developmental Services (2007). Autism Spectrum Disorders. Changes in the California Caseload An Update: June 1987 - June 2007.

Carver, C. S., & Scheier, M. F. (2000). Perspectives on personality (4th ed.), 5. Boston: Allyn and Bacon.

Chakrabarti, B., Dudbridge, F., Kent, L., Wheelwright, S., Hill Cawthorne, G., Allison, C., Banerjee-Basu, S., & Baron-Cohen, S. (2009). Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Research 2(3): 157-77.

Chawarska, K., Volkmar, F., & Klin, A. (2010). Limited attentional bias for faces in toddlers with autism spectrum disorders. Archives of General Psychiatry, 67(2):178-85.

Chimpanzee Sequencing and Analysis Consortium (2005). Initial sequence of the chimpanzee genome and comparison with the human genome. Nature, 437: 69-87.

Christakis, D. A. (2009). The effects of infant media usage: what do we know and what should we learn? Acta Paediatrica 98(1): 8-16.

Christakis, D. A. (2010). Internet addiction: a 21st century epidemic? BioMed Central Medicine. 2010; 8: 61.

Christakis, D. A., Gilkerson, J., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., Gray, S., Yapanel, U. (2009). Audible television and decreased adult words, infant vocalizations, and conversational turns: a population-based study Archives of Pediatrics & Adolescent Medicine. 2009;163(6):554-558.

Christakis, D. A., Zimmerman, F. J., DiGiuseppe, D. L. & McCarthy, C. A. (2004). Early Television Exposure and Subsequent Attentional Problems in Children. Pediatrics, 113: 708-13.

Doheny, K. (2009). Study shows some children may ‘move off’ the autism spectrum. WebMD Health News, May 11th.

Dunbar, R. I. M. (1992). Neocortex size as a constraint on group size in primates. Journal of Human Evolution, 20: 469-93.

Elman, J. L., Bates, E. A., Johnson, M. H., Karmiloff-Smit, A., Parisi, D. & Plunkett, K. (1998). Rethinking Innateness: A Connectionist Perspective on Development. Cambridge: MIT Press.

Elsabbagh, M., Volein, A., Csibra, G., Holmboe, K., Garwood, H., Tucker, L., Krljes, S., Baron-Cohen, S., Bolton, P., Charman, T., Baird, G., & Johnson, M. H. (2009). Neural Correlates of Eye Gaze Processing in the Infant Broader Autism Phenotype. Biological Psychiatry, 65: 31-8.

Emery, N. J. (2000). The eyes have it: the neuroethology, function and evolution of social gaze. Neuroscience and Biobehavioral Reviews, 24: 581-604.

Farroni, T., Csibra, G., Simion, F. & Johnson, M. H. (2002). Eye-contact detection in humans from birth. Proceedings of the National Academy of Sciences USA, 99(14): 9602-5. Visual stimulus photographs of direct and averted gaze.

Farroni, T., Johnson, M. H., Menon, E., Zulian, L., Faraguna, D., & Csibra, G. (2005). Newborns’ preference for face-relevant stimuli: Effects of contrast polarity. Proceedings of the National Academy of Sciences USA, 102(47) 17245-50.

Farroni, T., Menon, E., Rigato, S., & Johnson, M. H. (2007). The perception of facial expressions in newborns. European Journal of Developmental Psychology 4(1): 2-13.

Fraiberg, S. (1977). Insights from the Blind: Comparative Studies of Blind and Sighted Infants. New York: Basic Books.

Freedman, D. (1964). Smiling in infants and the issue of innate vs. acquired. Journal of Child Psychology and Psychiatry, 5: 171-84.

Fries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005). Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. Proceedings of the National Academy of Sciences USA, 102(47): 17237-40.

Frith U, ed. (1991). Autism and Asperger Syndrome, 89. Cambridge University Press.

Gans, C. & Parsons, T. S. (1973). Biology of the Reptiles, 4, Morphology D, 104. London: Academic Press.

Ganz, M. L., (2006). The costs of autism. In: Understanding Autism: From Basic Neuroscience to Treatment, ed. S.O. Moldin and J.L.R. Rubenstein, 475-502. New York: CRC Press.

Ganz, M. L., (2007). The lifetime distribution of the incremental societal costs of autism. Archives of Pediatric & Adolescent Medicine. 161(4):343-349.

Gergely, G. (2001). The obscure object of desire: ‘Nearly, but clearly not, like me.’ Contingency preference in normal children versus children with autism. Bulletin of the Menninger Clinic, 65: 411-26.

Gergely, G. & Watson, J. S. (1996). The social biofeedback theory of parental affect mirroring. International Journal of Psycho-Analysis, 77: 1181-212.

Gillberg, C. & Wing, L. (1999). Autism: not an extremely rare disorder. Acta Psychiatrica Scandinavica, 99(6): 399-406.

Grossmann, T., & Johnson, M. H. (2010). Selective prefrontal cortex responses to joint attention in early infancy. Biology Letters 6(4): 540-543.

Guastella, A. J., Einfeld, S. L., Gray, K., M., Rinehart, N., J., Tonge, B., J., Lambert, T., J. & Hickie, I., B. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry, 67 (7).

Haaf, R. A. & Bell, R. Q. (1967). A facial dimension in visual discrimination by human infants. Child Development, 38: 892-9.

Haith, M. M. (1966). The response of the human newborn to visual movement. Journal of Experimental Child Psychology, 3: 235-43.

Hamermesh, D. S., Frazis, H., & Stewart, J. (2005). Data watch: The American Time Use Survey. Journal of Economic Perspectives, 19: 221-32.

Hobson, P. (2002). The Cradle of Thought: Exploring the Origins of Thinking. London: Macmillan.

Hobson, R. P., Lee, A. & Brown, R. (1999). Autism and congenital blindness. Journal of Autism and Developmental Disorders, 29(1): 45-56.

Holland, J. (1995) Hidden Order: How Adaptation builds Complexity. Reading, MA: Perseus.

Holland, J. (1998). Emergence from chaos to order. Reading, MA: Perseus.

Hormatertz-Picciotto, I. & Delwiche, L. (2009), The rise of autism and the role of age in diagnosis. Epidemiology, 20(1): 84-90.

Jaffe, J., Beebe, B., Feldstein, S., Crown, C. L. & Jasnow, M. D. (2001). Rhythms of dialogue in infancy: coordinated timing in development. Monograph of the Society for Research in Child Development, 66(2): i-viii, 1-132.

James, I. (2003). Singular scientists. Journal of the Royal Society of Medicine. 96(1): 36-9.

Janzen, D. H., Hallwachs, W., & Burns, J. M. (2010). A tropical horde of counterfeit predator eyes. Proceedings of the National Academy of Sciences USA, 107(26): 11659-65.

Johnson, M. H. & Morton, J. (1991). Biology and Cognitive Development: The Case of Face Recognition. Oxford: Blackwell.

Kaiser Family Foundation (2003). Zero to six: electronic media in the lives of infants, toddlers, and preschoolers. Kaiser Family Foundation, Menlo Park, CA.

Kaiser Family Foundation (2006) The Media Family: Electronic Media in the Lives of Infants, Toddlers, Preschoolers, and their Parents. Kaiser Family Foundation: Menlo Park, CA.

Kaiser, M. D., Hudac, C. M., Shultza, S., Leea, S. M., Cheung, C., Berken, A. M., Deen, B.,Pitskel, N. B., Sugrue, D. R., Voos, A. C., Saulnier, C. A., Ventola, P., Wolf, J. M., Klin, A., Vander Wyk, B. C. & Pelphrey, K. A. (2010). Neural signatures of autism. Proceedings of the National Academy of Sciences, 107(49): 21223-21228. http://www.Pnas.Org/cgi/doi/10.1073/pnas.1010412107

Klin, A. & Jones, W. (2007). Embodied psychoanalysis? Or, on the confluence of psychodynamic theory and developmental science. In: Developmental Science and Psychoanalysis: integration and innovation, eds L. Mayes, P. Fonagy and M. Target, Karnac, London, 5-38.

Klin, A. & Jones, W. (2008) Altered face scanning and impaired recognition of biological motion in a 15-month-old infant with autism. Developmental Science 11(1): 40-46.

Klin, A., Jones, W., Schultz, R., Volkmar, F., & Cohen, D. (2002). Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism. Archives of General Psychiatry, 59(9): 809-16.

Klin, A., Lin, D. J., Gorrindo, P., Ramsay G., & Jones, W. (2009). Two-year-olds with autism orient to non-social contingencies rather than biological motion. Nature letters 459, 14 May.

Kogan, M. D., Blumberg, S. J., Schieve, L. A., Boyle, C. A., Perrin, J. M., Ghandour, R. M., Singh, G. K., Strickland, B. B., Trevathan, E., & van Dyck, P. C. (2009) National Children’s Health Survey Report: Prevalence of Parent-Reported Diagnosis of Autism Spectrum Disorder Among Children in the US, 2007. Pediatrics, 124(5): 1395-403.

Lachmann F. M. (2000). Transforming Aggression: Psychotherapy with the Difficult-to-Treat Patient. Northvale, NJ: Jason Aronson, 48-117.

Levin, S. A. (1998). Ecosystems and the biosphere as complex adaptive systems. Ecosystems 1: 431-6.

Loeuille, N. (2009). Evolution of communities and ecosystems. In: The Princeton Guide to Ecology, ed. S. A. Levin, 414-21. Princeton University Press.

Lovgren, S. (2005). Chimps, humans 96 percent the same, gene study finds. National Geographic News, August 31.

Maestro, S., Muratori, F., Barbieri, F., Casella, C., Cattaneo, V., Cavallaro, M. C., Cesari, A., Milone, A., Rizzo, L., Viglione, V., Stern, D. D. & Palacio-Espasa, F. (2001). Early behavioral development in autistic children: the first 2 years of life through home movies. Psychopathology, 34(3): 147-52.

McDowell, M. J. (2001). Principle of organization: a dynamic systems view of the archetype-as-such. Journal of Analytical Psychology, 46(4): 637-54. In Cogprints as: The three gorillas: an archetype orders a dynamic system.

McDowell, M. J. (2002). The image of the mother’s eye: autism and early narcissistic injury.

McDowell, M. J. (2004a). Autism, early narcissistic injury and self-organization: a role for the image of the mother’s eyes? Journal of Analytical Psychology 49(4): 495-520.

McDowell, M. J. (2004b). Is Autism Statistically Linked to Early Non-Maternal Child Care? Dynamical Psychology.

McKinney, M. L. & McNamara, K. J. (1991). Heterochrony: The Evolution of Ontogeny. New York: Plenum Press.

Michael, C. R. (1969). Retinal processing of visual images. Scientific American, May: 104-15.

Mitchel, M. (2009). Complexity, A Guided Tour. Oxford University Press, 178-82, 249.

Morgan, A. C., Bruschweiler-Stern, N. & Tronic, E. Z. (1998). Non-interpretive methods in psychoanalytic therapy: the ‘something more’ than interpretation. International Journal of Psycho-Analysis, 79: 903-31.

Muratori, M. & Maestro, S. (2007). Autism as a downstream effect of primary difficulties in intersubjectivity interacting with abnormal development of brain connectivity. International Journal for Dialogical Science 2(1): 93-118.

Olmsted, D., (2005a). The age of autism: the amish anomaly, Washington Times, April 18.

Olmsted, D., (2005b). The age of autism: Julia. Washington Times, April 19.

Poitras, C (2010). Recovery from Autism, UConn Today, 13 Sep.

Rapin, I. (1997). Autism. New England Journal of Medicine, 337(2): 97-104.

Rimland, B. (1964). Infantile autism: The Syndrome and its Implications for a Neural Theory of Behavior. New York: Appleton-Century-Crofts.

Rimmele, U., Hediger, K., Heinrichs, M., & Klaver, P. (2009). Oxytocin makes a face in memory familiar. Journal of Neuroscience 29(1): 38-42.

Rodier, P. M. (2000). The early origins of autism. Scientific American, February: 56-63.

Rutter, M. L., Kreppner, J. M. & O’Connor, T. G. (2001). Specificity and heterogeneity in children’s responses to profound institutional privation. British Journal of Psychiatry, 179: 97-103.

Saenko, S. V., Brakefield P. M., & Beldade, P. (2010). Single locus affects embryonic segment polarity and multiple aspects of an adult evolutionary novelty. BioMed Central Biology 2010, 8:111

Salapatek, P. (1975). Pattern perception in early infancy. In: Infant Perception: from Sensation to Cognition, I: Basic Visual Processes, eds. L. B. Cohen & P. Salapatek , 144-248. New York: Academic Press.

Scheffer, M., (2009). Alternative stable states and regime shifts in ecosystems. In: The Princeton Guide to Ecology, ed. S. A. Levin, 395-404. Princeton University Press.

Scherer, S. W. et al. (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466: 368-72.

Sharma, J., Alessandra, A. & Sur, M. (2000). Induction of visual orientation modules in auditory cortex. Nature, 404: 841-7.

Sigman, M. & Capps, L. (1997). Children with Autism: a Developmental Perspective, 147-74. Cambridge: Harvard University Press.

Simion, F., Regolin, L., and Bulf, H. (2008). A predisposition for biological motion in the newborn baby. Proceedings of the National Academy of Sciences 105 (2) 809-813. ; Supporting movies:

Spitz, R. A. & Wolf, K. M. (1946). The smiling response: a contribution to the ontogenesis of social relations. Genetic Psychology Monographs, 34: 57- 125.

Stern, D. N. (1977). The First Relationship. Cambridge: Harvard University Press.

Stern, D. N. (1985). The Interpersonal World of the Infant. New York: Basic Books.

Stern, D. N., Sander, L. W., Nahum, J. P., Harrison, A. M., Lyons-Ruth, K., Morgan, A. C., Bruschweiler-Stern, N. & Tronic, E. Z. (1998). Non-interpretive methods in psychoanalytic therapy: the ‘something more’ than interpretation. International Journal of Psycho-Analysis, 79: 903-31.

Stolorow, R. D. (1967). Dynamic, dyadic, intersubjective systems: an evolving paradigm for psychoanalysis. Psychoanalytic Psychology, 14(3): 337-346.,%20Robert%20-%20Dynamic,



Stromland, K., Sjogreen, L., Miller, M., Gillberg, C., Wentz, E., Johansson, M., Nylen, O., Danielsson, A., Jacobsson, C., Andersson, J. & Fernell, E. (2002). Mobius sequence - a Swedish multidiscipline study. European Journal of Paediatric Neurology, 6(1): 35-45.

Trepagnier, C. (1998). ‘Autism etiology: a face-processing perspective’. Brain and Cognition, 37(1) 158-60.

Trevarthen C., & Aitken K. J. (2001). Infant intersubjectivity: research, theory, and clinical applications. Journal of Child Psychology and Psychiatry 421:3-48.

Ungerer, J. A. (1989). The early development of autistic children: implications for defining primary deficits. In Autism: Nature, Diagnosis and Treatment, ed. G. Dawson. New York: Guildford Press, pp. 85-8

Waldman, M., Nicholson, S. & Adilov, N., (2006) Does television cause autism? (complete paper): (abstract): Working Paper 12632 National Bureau of Economic Research 1050 Massachusetts Avenue Cambridge, MA 02138.

Waldman, M., Nicholson, N. A., & Williams, J. (2008). Autism prevalence and precipitation rates in California, Oregon, and Washington counties. Archive of Pediatric Adolescent Medicine, 162(11): 1026-34.

Winnicott, D. W. (1971/86) Playing and Reality. New York: Routledge.

Wood, W. B. and R. A. Crowther, 1983. Long Tail Fibers: Genes, Proteins, Assembly, and Structure. In: Bacteriophage T4, eds. C. K. Mathews, E. M. Kutter, G. Mosig, and P. B. Berget, 263. Washington, D. C.: American Society for Microbiology.

Yazbak, F., E. (2003). Autism in the United States: a perspective. Journal of American Physicians and Surgeons, 8(4): 103.


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