Amniotic-Fluid Ingestion Enhances the Central Analgesic Effect of Morphine

DiPirro, Jean M. and Thompson, Alexis C. and Kristal, Dr. Mark B. (1991) Amniotic-Fluid Ingestion Enhances the Central Analgesic Effect of Morphine. [Journal (Paginated)]

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Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.

Item Type:Journal (Paginated)
Keywords:POEF, analgesia, pain, rats, morphine, opioids, placenta, quaternary naltrexone, amniotic fluid, placentophagia, naltrexone methobromide
Subjects:Psychology > Psychobiology
Psychology > Physiological Psychology
Neuroscience > Neuropharmacology
Neuroscience > Behavioral Neuroscience
ID Code:6211
Deposited By: Kristal, Mark B.
Deposited On:19 Sep 2008 13:55
Last Modified:11 Mar 2011 08:57


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