Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy

Babu, Suresh and Shetty, Jeevan K and Mungli, Prakash (2010) Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy. [Journal (On-line/Unpaginated)]

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Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.

Item Type:Journal (On-line/Unpaginated)
Keywords:MDA; Total thiols; Myocardial infarction; Reperfusion injury
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6978
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:22 Nov 2010 14:20
Last Modified:11 Mar 2011 08:57

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