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Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy

Sharma, Gaurav Mrinal (2008) Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy. [Journal (On-line/Unpaginated)]

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Abstract

Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer

Item Type:Journal (On-line/Unpaginated)
Keywords:HIF, HIF-1α, Hypoxia, Malignancy, Cancer, Cancer Therapy
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6202
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:19 Sep 2008 13:59
Last Modified:11 Mar 2011 08:57

References in Article

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